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Table 2 Effect of different antibiotic treatments on attached B. burgdorferi biofilm glycosaminoglycan (GAG) content at 50 µM concentration evaluated with Dimethylmethylene Blue Assay for Glycosaminoglycan after 72 h

From: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

Antibiotics

10 µM GAG % ± %SD

50 µM GAG % ± %SD

Control (PBS)

100%

100%

DDS

79% ± 5.8

68% ± 3.6

DOXY

76% ± 4.2

73% ± 7.2

RIF

75% ± 6.3

70% ± 5.8

CEF

78% ± 5.2

76% ± 7.4

AZ

82% ± 6.6

79% ± 8.2

DDS + DOXY

70% ± 8.2

69% ± 5.3

DDS + DOXY + RIF

69% ± 4.2

70% ± 7.3

DDS + DOXY + RIF + AZ

75% ± 6.8

62% ± 5.4

  1. The table summarizes that mean % of the residual GAG amounts with ± SD compared to the PBS treated control. N = 20
  2. DDS dapsone, DOXY doxycycline, RIF rifampin, CEF cefuroxime, AZ azithromycin
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BMC Research Notes

ISSN: 1756-0500

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