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Table 2 Effect of different antibiotic treatments on attached B. burgdorferi biofilm glycosaminoglycan (GAG) content at 50 µM concentration evaluated with Dimethylmethylene Blue Assay for Glycosaminoglycan after 72 h

From: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

Antibiotics 10 µM GAG % ± %SD 50 µM GAG % ± %SD
Control (PBS) 100% 100%
DDS 79% ± 5.8 68% ± 3.6
DOXY 76% ± 4.2 73% ± 7.2
RIF 75% ± 6.3 70% ± 5.8
CEF 78% ± 5.2 76% ± 7.4
AZ 82% ± 6.6 79% ± 8.2
DDS + DOXY 70% ± 8.2 69% ± 5.3
DDS + DOXY + RIF 69% ± 4.2 70% ± 7.3
DDS + DOXY + RIF + AZ 75% ± 6.8 62% ± 5.4
  1. The table summarizes that mean % of the residual GAG amounts with ± SD compared to the PBS treated control. N = 20
  2. DDS dapsone, DOXY doxycycline, RIF rifampin, CEF cefuroxime, AZ azithromycin