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Table 3 Correlations of scores of inflammatory and oxidative stress biomarkers

From: Serum inflammatory and oxidative stress biomarkers levels are associated with pain intensity, pressure pain threshold and quality of life in myofascial pain syndrome

Variable Resting pain Pain intensity with activity Night pain PPT Pain duration PF RP RE EF EW SF P GH PH MH
With clinical findings and quality of life in patient (case) groupa
hs-CRP r = 0.349 (0.171–527) r = 0.259 (−0.067–0.451) r = 0.285 (0.089–0.481) r = 0.269 (−0.070–0.468) r = 0.283 (0.121–0.445) r = −0.265 (−0.540–0.010) r = −0.081 (−0.377–0.215) r = −0.313 (−0.554–0.072) r = −0.379 (−0.661–0.097) r = −0.390 (−0.720–0.060) r = −0.381 (−0.733–0.029) r = −0.324 (−0.644–0.04) r = −0.083 (−0.396–0.230) r = −0.190 (−0.496–0.116) r = −0.524 (−0.776–0.272)
p = 0.001 p = 0.049 p = 0.043 p = 0.047 p = 0.007 p = 0.079 p = 0.596 p = 0.036 p = 0.010 p = 0.008 p = 0.010 p = 0.030 p = 0.589 p = 0.212 p = 0.001
TAC r = −0.312 (−0.609–0.015) r = −0.116 (−0.422–0.190) r = −0.253 (−0.551–0.045) r = −0.041 (−0.348–0.266) r = 0.180 (−0.122–0.482) r = 0.410 (0.130–0.690) r = 0.615 (0.373–0.857) r = 0.123 (−0.182–0.428) r = −0.012 (−0.319–0.295) r = −0.104 (−0.410–0.202) r = 0.253 (−0.044–0.551) r = 0.228 (−0.072–0.527) r = 0.415 (0.135–0.695) r = 0.359 (0.072–0.646) r = 0.119 (−0.186–0.424)
p = 0.037 p = 0.447 p = 0.093 p = 0.789 p = 0.236 p = 0.005 p < 0.001 p = 0.421 p = 0.939 p = 0.497 p = 0.093 p = 0.132 p = 0.005 p = 0.016 p = 0.436
MDA r = 0.241 (−0.043–0.525) r = 0.287 (−0.008–0.581) r = 0.082 (−0.224–0.389) r = 0.234 (−0.064–0.533) r = 0.259 (−0.038–0.556) r = 0.150 (−0.154–0.454) r = 0.123 (−0.182–0.428) r = 0.041 (−0.266–0.348) r = 0.028 (−0.280–0.335) r = 0.033 (−0.274–0.340) r = 0.085 (−0.222–0.391) r = 0.271 (−0.025–0.567) r = 0.008 (−0.300–0.315) r = 0.161 (−0.143–0.465) r = 0.048 (−0.260–0.355)
p = 0.110 p = 0.056 p = 0.592 p = 0.121 p = 0.086 p = 0.325 p = 0.421 p = 0.790 p = 0.856 p = 0.829 p = 0.580 p = 0.072 p = 0.959 p = 0.291 p = 0.756
SOD r = −0.184 (−0.457–0.089) r = −0.076 (−0.383–0.230) r = −0.101 (−0.407–0.205) r = −0.029 (−0.336–0.279) r = 0.277 (−0.072–0.626) r = 0.077 (−0.229–0.384) r = 0.029 (−0.279–0.336) r = 0.124 (−0.181–0.429) r = 0.120 (−0.186–0.425) r = −0.114 (−0.420–0.191) r = −0.033 (−0.340–0.275) r = 0.133 (−0.172–0.438) r = 0.057 (−0.250–0.364) r = 0.077 (−0.229–0.384) r = 0.057 (−0.250–0.364)
p = 0.225 p = 0.618 p = 0.507 p = 0.851 p = 0.133 p = 0.614 p = 0.852 p = 0.416 p = 0.433 p = 0.455 p = 0.831 p = 0.383 p = 0.709 p = 0.614 p = 0.709
PLA2 r = 0.263 (−0.020–0.546) r = 0.131 (−0.165–0.427) r = 0.140 (−0.131–0.411) r = 0.025 (−0.238–0.288) r = −0.074 (−0.373–0.225) r = −0.137 (−0.474–0.200) r = −0.383 (−0.604–0.162) r = −0.314 (−0.544–0.084) r = −0.140 (−0.453–0.173) r = −0.152 (−0.436–0.132) r = −0.086 (−0.384–0.212) r = −0.328 (−0.560–0.096) r = −0.233 (−0.498–0.032) r = −0.310 (−0.488–0.132) r = −0.210 (−0.587–0.167)
p = 0.071 p = 0.393 p = 0.360 p = 0.869 p = 0.361 p = 0.369 p = 0.009 p = 0.035 p = 0.357 p = 0.319 p = 0.576 p = 0.028 p = 0.124 p = 0.038 p = 0.165
With quality of life in control (healthy) groupa
hs-CRP r = −0.178 (−0.470–0.123) r = −0.108 (−0.399–0.182) r = −0.265 (−0.559–0.030) r = 0.001 (−0.305–0.307) r = −0.423 (−0.700–0.147) r = −0.203 (−0.502–0.096) r = −0.295 (−0.600–0.123) r = −0.071 (−0.399–0.257) r = −0.222 (−0.515–0.071) r = −0.351 (−0.637–0.065)
p = 0.079 p = 0.094 p = 0.077 p = 0.994 p = 0.004 p = 0.178 p = 0.058 p = 0.240 p = 0.104 p = 0.017
TAC r = 0.329 (0.038–0.619) r = 0.615 (0.372–0.857) r = 0.444 (0.169–0.720) r = 0.246 (−0.052–0.544) r = 0.225 (−0.074–0.525) r = 0.450 (0.175–0.724) r = 0.489 (0.221–0.757) r = 0.618 (0.377–0.860) r = 0.667 (0.438–0.896) r = 0.577 (0.326–0.828)
p = 0.027 p < 0.001 p = 0.002 p = 0.103 p = 0.137 p = 0.002 p = 0.001 p < 0.001 p < 0.001 p < 0.001
MDA r = −0.296 (−0.590–0.003) r = −0.637 (−0.874–−0.399) r = −0.314 (−0.606–0.022) r = −0.280 (−0.575–0.016) r = −0.510 (−0.775–−0.245) r = −0.291 (−0.585–0.004) r = −0.553 (−0.810–−0.297) r = −0.642 (−0.878–−0.406) r = −0.697 (−0.918–−0.477) r = −0.523 (−0.785–−0.261)
p = 0.048 p < 0.001 p = 0.036 p = 0.063 p < 0.001 p = 0.053 p < 0.001 p < 0.001 p < 0.001 p < 0.001
SOD r = 0.376 (0.091–0.661) r = 0.681 (0.456–0.906) r = 0.407 (0.126–0.688) r = 0.208 (−0.093–0.508) r = 0.261 (−0.036–0.558) r = 0.080 (−0.195–0.355) r = 0.129 (−0.170–0.429) r = 0.557 (0.326–0.828) r = 0.716 (0.501–0.930) r = 0.546 (0.288–0.803)
p = 0.011 p < 0.001 p = 0.005 p = 0.171 p = 0.084 p = 0.315 p = 0.208 p < 0.001 p < 0.001 p < 0.001
PLA2 r = −0.328 (−0.619–0.037) r = −0.381 (−0.665–0.097) r = −0.290 (−0.584–0.004) r = −0.203 (−0.504–0.098) r = −0.339 (−0.928–0.050) r = −0.548 (−0.805–0.290) r = −0.424 (−0.702–0.145) r = −0.412 (−0.692–0.131) r = −0.486 (−0.754–0.217) r = −0.532 (−0.793–0.272)
p = 0.028 p = 0.010 p = 0.053 p = 0.181 p = 0.023 p < 0.001 p = 0.004 p = 0.005 p = 0.001 p < 0.001
  1. Unadjusted linear regression was used. Values of p < 0.05 are considered as statistically significant
  2. PPT pressure pain threshold, hs-CRP high-sensitive C-reactive protein, MDA malondialdehyde, PLA2 phospholipase A2, SOD superoxide dismutase, TAC total antioxidant capacity, EF energy/fatigue, EW emotional wellbeing, GH general health, MH mMental health, P pain, PF physical function, PH physical health, RE role limitation due to emotional problems, RP role limitation due to physical health, SF social function