From: Pharmaceutical quality of seven brands of diclofenac tablet on the Saudi market
Code | Weight, n = 20 | Active substance contentb, n = 20 | Breaking force, n = 10 | Friabilityc, n = 20 | Disintegrationd Phosphate buffer, n = 6 | Dissolutione Phosphate buffer, n = 8 | ||
---|---|---|---|---|---|---|---|---|
Mean (SD), mg | Rangea, % from mean | Mean (SD), mg | Mean (SD), % of label | Mean (SD), kg/cm2 | % loss | Range Hour: minute: second | Mean (range) release at 60 min, % of label | |
R1 | 317.0 (8.1) | 95–104 | 50.5 (1.7) | 100.9 (3.4) | 12.2 (1.3) | 0.0014 | 00:13:25 to 00:14:30 | 94 (89–99) |
G1 | 262.4 (2.1) | 99–102 | 54.6 (1.9) | 109.2 (3.8) | 9.3 (0.4) | 0.0013 | 00:14:30 to 00:17:20 | 96 (84–104) |
G2 | 264.6 (2.6) | 99–102 | 51.1 (2.8) | 102.1 (5.7) | 6.4 (0.6) | 0.0009 | 00:07:05 to 00:08:55 | 95 (66–103)g |
G3 | 204.8 (1.7) | 98–102 | 49.4 (1.3) | 98.8 (2.7) | 13.3 (1.0) | 0.0012 | 00:05:10 to 00:05:50 | 89 (78–94)g |
G4 | 205.6 (1.6) | 99–101 | 50.2 (2.1) | 100.4 (4.3) | 11.4 (0.9) | 0.0007 | 00:04:05 to 00:04:50 | 100 (93–105) |
R2 | 302.3 (2.2) | 99–102 | 105.6 (4.2) | 105.6 (4.2) | 12.9 (1.8) | 0.0012 | 01:59:16 to 02:14:49f | See Fig. 1 |
G5 | 263.9 (2.9) | 98–102 | 100.4 (3.9) | 100.4 (3.9) | 8.6 (0.5) | 0.0261 | 01:58:02 to 02:13:56f | See Fig. 1 |