Embryonic stage | Gene editing method | Cas9/gRNAcomplex* | No. of embryos examined | No. (%) of embryos | |
---|---|---|---|---|---|
Cleavage** | Developed to blastocysts | ||||
1-cell | MI | āāā | 201 | 138 (68.7āĀ±ā2.6)a | 21 (10.5āĀ±ā1.7)a |
ā+ā | 248 | 155 (62.4āĀ±ā2.9)a | 20 ( 8.1āĀ±ā1.1)a | ||
EP | āāā | 210 | 192 (91.5āĀ±ā1.7)b | 38 (18.1āĀ±ā1.4)ab | |
ā+ā | 250 | 230 (92.0āĀ±ā0.9)b | 40 (16.0āĀ±ā3.1)ab | ||
2-cells | MI | āāā | 105 | 78 (74.3āĀ±ā1.7)a | 19 (18.2āĀ±ā1.8)ab |
ā+ā | 119 | 73 (61.5āĀ±ā6.2)a | 15 (13.4āĀ±ā6.4)a | ||
EP | āāā | 105 | 91 (86.9āĀ±ā1.9)b | 34 (32.6āĀ±ā1.9)c | |
ā+ā | 128 | 114 (89.7āĀ±ā4.3)b | 33 (26.3āĀ±ā7.7)bc |