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Table 1 Restricted mean survival time (RMST) differences between treatment groups at three pre-specified landmarks (t*)

From: Time-dependent treatment effects of metronomic chemotherapy in unfit AML patients: a secondary analysis of a randomised controlled trial

Landmark t* (days) Metronomic chemotherapy (n = 40) Palliative treatment (n = 41) Treatment effect p value
Number at risk RMST (95% CI) Number at risk RMST (95% CI) RMST Difference (95% CI)
90 20 73.0 (65.3–80.7) 14 59.7 (50.9–68.5) + 13.3 (1.9 to 24.7) 0.022
180 7 111.1 (92.3–129.8) 6 82.2 (64.4–100.0) + 28.9 (3.3 to 54.4) 0.027
365 1 134.2 (101.5–166.9) 1 93.9 (68.0–119.7) + 40.4 (− 1.3 to 82.0) 0.058
  1. CI confidence interval, RMST restricted mean survival time, t* pre-specified time points for estimating the restricted mean survival time