Skip to main content

Table 1 Restricted mean survival time (RMST) differences between treatment groups at three pre-specified landmarks (t*)

From: Time-dependent treatment effects of metronomic chemotherapy in unfit AML patients: a secondary analysis of a randomised controlled trial

Landmark t* (days)

Metronomic chemotherapy (n = 40)

Palliative treatment (n = 41)

Treatment effect

p value

Number at risk

RMST (95% CI)

Number at risk

RMST (95% CI)

RMST Difference (95% CI)

90

20

73.0 (65.3–80.7)

14

59.7 (50.9–68.5)

+ 13.3 (1.9 to 24.7)

0.022

180

7

111.1 (92.3–129.8)

6

82.2 (64.4–100.0)

+ 28.9 (3.3 to 54.4)

0.027

365

1

134.2 (101.5–166.9)

1

93.9 (68.0–119.7)

+ 40.4 (− 1.3 to 82.0)

0.058

  1. CI confidence interval, RMST restricted mean survival time, t* pre-specified time points for estimating the restricted mean survival time