Table 2 Association of LEPR rs1137101 with obesity measures and metabolic parameters in the overall study group and overweight or obese subjects (BMI ≥ 25 kgm−2)
Overall study group | Overweight or obese (BMI ≥ 25 kgm−2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
AA n = 107 | AG n = 272 | GG n = 151 | p | p* | AA n = 53 | AG n = 141 | GG n = 70 | p | p* | |
BMI (kgm−2) | 24.4 ± 4.1 | 25.1 ± 4.1 | 25.2 ± 4.5 | 0.28 | 0.31 | 27.6 ± 2.6 | 28.2 ± 2.8 | 29.0 ± 3.3 | 0.03 | 0.04 |
WC(cm) | 88.0 ± 10.7 | 89.4 ± 10.6 | 89.8 ± 11.3 | 0.41 | 0.36 | 95.2 ± 7.4 | 95.9 ± 7.7 | 98.4 ± 8.4 | 0.04 | 0.02 |
WHR | 0.92 ± 0.07 | 0.92 ± 0.07 | 0.92 ± 0.06 | 0.78 | 0.94 | 0.94 ± 0.07 | 0.94 ± 0.07 | 0.94 ± 0.06 | 0.89 | 0.94 |
FBS (mmol/l) | 5.3 ± 2.5 | 5.6 ± 3.9 | 5.2 ± 2.0 | 0.45 | 0.65 | 5.2 ± 1.9 | 5.6 ± 2.5 | 5.4 ± 2.2 | 0.53 | 0.52 |
TC (mmol/l) | 5.5 ± 0.9 | 5.8 ± 1.2 | 5.8 ± 2.1 | 0.41 | 0.45 | 5.4 ± 1.0 | 5.8 ± 1.3 | 5.9 ± 2.7 | 0.18 | 0.19 |
LDL-C (mmol/l) | 3.5 ± 0.9 | 3.8 ± 1.7 | 4.0 ± 3.3 | 0.19 | 0.19 | 3.4 ± 1.0 | 3.8 ± 2.2 | 4.5 ± 4.7 | 0.08 | 0.09 |
HDL-C (mmol/l) | 1.3 ± 0.3 | 1.5 ± 1.5 | 1.4 ± 0.3 | 0.35 | 0.52 | 1.3 ± 0.3 | 1.4 ± 0.3 | 1.4 ± 0.3 | 0.16 | 0.38 |
TGL (mmol/l) | 3.3 ± 1.6 | 3.4 ± 1.7 | 3.4 ± 2.6 | 0.49 | 0.56 | 3.3 ± 1.4 | 3.6 ± 1.8 | 3.8 ± 3.3 | 0.62 | 0.45 |