Skip to main content

Table 2 Neuropsychological test scores at baseline, 7-days and 3 months, and reliability statistics

From: Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction

 

Mean ± SD per time point

Repeated measures ANOVA

Baseline to 7 days

Baseline to 3 months

 

Baseline

7 days

3 months

F-value

p-value

ICC (95% CI)

SRD

Pairwise

p-value

ICC (95% CI)

SRD

Pairwise p-value

Computerized tests [CANTAB]

 Paired associates

15.56 ± 4.82

17.82 ± 4.06

16.20 ± 3.73

8.95

0.001

0.72 (0.39, 0.86)**

7.09

<0.001

0.78 (0.61, 0.88)**

6.25

0.241

 Verbal recognition—free recall

6.02 ± 1.84

6.58 ± 1.71

6.40 ± 1.68

2.76

0.074

0.72 (0.48, 0.84)**

2.72

0.027

0.68 (0.43, 0.82)**

2.88

0.148

 Verbal recognition—recognition

22.11 ± 2.15

21.18 ± 2.27

22.07 ± 1.86

9.29

<0.001

0.75 (0.49, 0.87)**

2.97

0.002

0.85 (0.72, 0.92)**

2.33

0.841

 Simple reaction timea (ms)

314.6 ± 98.5

304.5 ± 97.9

299.2 ± 58.6

0.78

0.463

0.85 (0.73, 0.92)**

106.04

0.350

0.64 (0.34, 0.80)**

166.22

0.217

 Spatial span

5.40 ± 1.12

5.22 ± 0.85

5.56 ± 0.99

2.39

0.104

0.63 (0.33, 0.80)*

1.88

0.253

0.60 (0.28, 0.78)*

1.95

0.360

Non-computerized tests

 Grooved Pegboardb

88.40 ± 21.43

85.87 ± 21.39

85.97 ± 21.06

1.90

0.163

0.94 (0.89, 0.97)**

14.31

0.091

0.92 (0.86, 0.96)**

16.64

0.126

 Trail-Making-A (s)

47.29 ± 15.69

43.98 ± 15.55

45.54 ± 16.87

1.01

0.372

0.67 (0.41, 0.82)**

24.91

0.158

0.78 (0.60, 0.88)**

20.40

0.402

 Trail-Making-Bc (s)

103.40 ± 42.15

92.37 ± 37.02

92.36 ± 41.49

2.01

0.146

0.69 (0.44, 0.83)**

64.56

0.090

0.78 (0.59, 0.88)**

55.17

0.039

  1. Pairwise p-values refer to pairwise comparison of baseline to 7 days and baseline to 3 months respectively
  2. Maximum scores: PAL 26; VRM free recall 12; VRM delayed recognition 24; SSP 9; GP 300 s; TMT-A 180 s; TMT-B 300 s
  3. All other analyses based on n = 45
  4. ANOVA analyses of variance, CANTAB Cambridge Neuropsychological Test Automated Battery, CI confidence interval, ICC intraclass correlation coefficient, SRD smallest real difference
  5. *p < 0.01; **p < 0.001
  6. aFor analysis of baseline to 3 months and ANOVA including pairwise comparison, n = 44 for SRT (baseline mean 315.04 ± 99.53 s for n = 44 sample)
  7. bFor analysis of baseline to 3 months and ANOVA including pairwise comparison, n = 44 for GP (baseline mean 88.61 ± 21.63 s for n = 44 sample)
  8. cFor analysis of baseline and 7 days and ANOVA including pairwise comparison, n = 44 for TMT-B (baseline mean 102.30 ± 41.97 s for n = 44 sample)