Mean ± SD per time point | Repeated measures ANOVA | Baseline to 7 days | Baseline to 3 months | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 7 days | 3 months | F-value | p-value | ICC (95% CI) | SRD | Pairwise p-value | ICC (95% CI) | SRD | Pairwise p-value | |
Computerized tests [CANTAB] | |||||||||||
Paired associates | 15.56 ± 4.82 | 17.82 ± 4.06 | 16.20 ± 3.73 | 8.95 | 0.001 | 0.72 (0.39, 0.86)** | 7.09 | <0.001 | 0.78 (0.61, 0.88)** | 6.25 | 0.241 |
Verbal recognition—free recall | 6.02 ± 1.84 | 6.58 ± 1.71 | 6.40 ± 1.68 | 2.76 | 0.074 | 0.72 (0.48, 0.84)** | 2.72 | 0.027 | 0.68 (0.43, 0.82)** | 2.88 | 0.148 |
Verbal recognition—recognition | 22.11 ± 2.15 | 21.18 ± 2.27 | 22.07 ± 1.86 | 9.29 | <0.001 | 0.75 (0.49, 0.87)** | 2.97 | 0.002 | 0.85 (0.72, 0.92)** | 2.33 | 0.841 |
Simple reaction timea (ms) | 314.6 ± 98.5 | 304.5 ± 97.9 | 299.2 ± 58.6 | 0.78 | 0.463 | 0.85 (0.73, 0.92)** | 106.04 | 0.350 | 0.64 (0.34, 0.80)** | 166.22 | 0.217 |
Spatial span | 5.40 ± 1.12 | 5.22 ± 0.85 | 5.56 ± 0.99 | 2.39 | 0.104 | 0.63 (0.33, 0.80)* | 1.88 | 0.253 | 0.60 (0.28, 0.78)* | 1.95 | 0.360 |
Non-computerized tests | |||||||||||
Grooved Pegboardb | 88.40 ± 21.43 | 85.87 ± 21.39 | 85.97 ± 21.06 | 1.90 | 0.163 | 0.94 (0.89, 0.97)** | 14.31 | 0.091 | 0.92 (0.86, 0.96)** | 16.64 | 0.126 |
Trail-Making-A (s) | 47.29 ± 15.69 | 43.98 ± 15.55 | 45.54 ± 16.87 | 1.01 | 0.372 | 0.67 (0.41, 0.82)** | 24.91 | 0.158 | 0.78 (0.60, 0.88)** | 20.40 | 0.402 |
Trail-Making-Bc (s) | 103.40 ± 42.15 | 92.37 ± 37.02 | 92.36 ± 41.49 | 2.01 | 0.146 | 0.69 (0.44, 0.83)** | 64.56 | 0.090 | 0.78 (0.59, 0.88)** | 55.17 | 0.039 |