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Fig. 3 | BMC Research Notes

Fig. 3

From: R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability

Fig. 3

RSPO2 deletion increases lung permeability, as determined by a FITC-dextran assay. a A significant increase in average plasma dextran concentration (ug/ml) was observed in RSPO2−/− mice compared to identically treated RSPO2+/+ mice 48 h after TM administration. b The movement of FITC-Dextran into normal alveolar capillaries (right side) and damaged alveolar capillaries (left side) during a murine model of endothelial cell barrier damage. Shown are the two crucial cell barriers, epithelial cells and endothelial cells. After intranasal instillation of FITC-Dextran solution, FITC-labeled molecules travel through the interalveolar space and interstitium into alveolar capillaries. Each dot represents the average of each experimental group in each of n = 3 independent experiments. Statistical significance was demonstrated when mice from the control group and experimental group were averaged within each of the independent experiments to control for the inherent variability in FITC-Dextran administration. When individual mice were pooled regardless of experiment, the results show a very similar trend as the averaged group, though not statistically significant. * = A P value of less than 0.05 was considered significant

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