Table 3 Sensitivity and specificity of individual signs, and the 7-sign algorithm for identification of the sick infant requiring hospital admission, for each age group
From: Clinical signs predictive of severe illness in young Pakistani infants
Signs | Ages 0–6 days n = 1633 | Ages 7–27 days n = 817 | Ages 28–59 days n = 500 | |||
|---|---|---|---|---|---|---|
Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
History of difficult feeding | 26.0 (19.7, 33.0) | 97.2 (96.2, 98.0) | 24.1 (13.9, 37.2) | 96.6 (95.0, 97.8) | 15.0 (5.7, 29.8) | 93.7 (91.1, 95.7) |
Movement only when stimulated | 22.2 (17.5, 27.5) | 99.7 (99.4, 99.8) | 20.7 (11.2, 33.4) | 99.6 (98.8, 99.9) | 7.3 (1.5, 19.9) | 99.8 (98.8, 100.0) |
Temperature < 35.5 | 13.0 (8.5, 18.7) | 98.0 (97.1, 98.7) | 5.2 (1.1, 14.4) | 98.9 (97.9, 99.5) | 2.4 (0.1, 12.9) | 99.3 (98.1, 99.9) |
Temperature ≥ 37.5 | 24.7 (18.6, 31.7) | 90.8 (89.2, 92.3) | 27.6 (16.7, 40.9) | 96.3 (94.6, 97.5) | 12.2 (4.1, 26.2) | 96.0 (93.8, 97.6) |
Respiratory Rate > 60 | 51.4 (43.9, 58.8) | 81.6 (79.5, 83.5) | 46.6 (33.3, 60.1) | 92.1 (89.9, 93.9) | 56.1 (39.7, 71.5) | 92.2 (89.3, 94.4) |
Severe chest indrawing | 12.4 (8.0, 18.1) | 99.7 (99.2, 99.9) | 24.1 (13.9, 37.2) | 100.0 (99.5, 100.0) | 39.0 (24.2, 55.5) | 97.6 (95.8, 98.8) |
History of convulsions | 9.7 (5.9, 14.9) | 99.5 (99.0, 99.8) | 1.7 (0.0, 9.2) | 98.7 (97.6, 99.4) | 9.8 (2.7, 23.1) | 98.5 (96.9, 99.4) |
7-sign algorithm | 85.9 (80.1, 90.6) | 71.6 (69.2, 74.0) | 72.4 (59.1, 83.3) | 83.1 (80.3, 85.7) | 80.5 (65.1, 91.2) | 80.2 (76.2, 83.7) |