Skip to main content
Fig. 1 | BMC Research Notes

Fig. 1

From: Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients

Fig. 1

The new variants in CR-2 domain of EGFR gene in cancer patients and healthy subjects. a Alignment of nucleic and amino acid sequences of exon 13 of the EGFR gene showing the new SNP 1536C > T (P512P) marked with an asterisk. b Chromatographic patterns of direct sequencing showing new mutation in exon 13 of EGFR, 1536 C > T (P512P) (indicated by the arrows). c Alignment of nucleic and amino acid sequences of exon 14 of the EGFR gene showing the novel mutation 1468G > A (V550M) marked with an asterisk. d Chromatographic patterns of direct sequencing of EGFR exon 14 showing the novel mutation 1648 G > A (V550M) (pointed by an arrows). e Alignment of nucleic and amino acid sequences of exon 15 of the EGFR gene showing the new mutations 1769A > G (H590R), 1804G > A (E602K), and 1815C > T (T605T) respectively, all marked with an asterisk. f–h Chromatographic patterns of direct sequencing of EGFR exon 15 showing the novel mutations 1769A > G (H590R), 1804G > A (E602K), and 1815C > T (T605T) resepectively, the sequence change detected pointed by an arrows. i Alignment of nucleic and amino acid sequences of exon 16 of the EGFR gene showing two new variants 1896T > A (G632G) and 1913C > T (T638M) respectively marked with an asterisk. j, k Chromatographic patterns of direct sequencing of EGFR exon 16 showing the new mutation 1896 T > A (G632G) and the novel SNP1913 C > T (T638M), respectively

Back to article page