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Table 1 Novel genetic alterations in CR2 domain: allele and genotype frequencies

From: Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients

Exon SNP ID Type of Samples (n) Allele AF (%) Genotype GF (%) Samples (n) HWE
p values
Fisher’s
p value
13 SNP
1536 C > T
rs374670788
Control (114) C
T
99
1
CC
CT
TT
99
1
0
113
1
0
0.962
Colon (54) C
T
99
1
CC
CT
TT
98
2
0
53
1
0
0.945 0.540
Bladder (16) C
T
97
3
CC
CT
TT
94
6
0
15
1
0
0.897 0.231
14 Mutation
1648 G > A
Control (113) G
A
100
0
GG
GA
AA
100
0
0
113
0
0
Colon (64) G
A
95.3
4.7
GG
GA
AA
91
9
0
58
6
0
0.693 0.0019
Lung (10) G
A
75
25
GG
GA
AA
50
50
0
5
5
0
0.291 0.000001
Ovary (11) G
A
86.33
13.64
GG
GA
AA
73
27
0
8
3
0
0.600 0.0005
Bladder (16) G
A
81.25
18.75
GG
GA
AA
63
38
0
10
6
0
0.355 0.000001
Thyroid (9) G
A
88.89
11.11
GG
GA
AA
78
22
0
7
2
0
0.707 0.004
15 Mutation
1769 A > G
Control (97) A
G
100
0
AA
AG
GG
100
0
0
97
0
0
Colon (37) A
G
99
1
AA
AG
GG
97
3
0
36
1
0
0.933 0.246
Mutation
1804 G > A
Control (97) A
G
100
0
AA
AG
GG
100
0
0
97
0
0
Colon (37) G
A
99
1
GG
GA
AA
97
3
0
36
1
0
0.933 0.246
Mutation
1815 C > T
Control (97) C
T
100
0
CC
CT
TT
100
0
0
97
0
0
 
Colon (37) C
T
99
1
CC
CT
TT
97
3
0
36
1
0
0.933 0.246
16 Mutation
1896T > A
Control (114) T
A
100
0
TT
TA
AA
100
0
0
114
0
0
Colon (64) T
A
98.4
1.6
TT
TA
AA
90
10
0
62
2
0
0.898 0.127
Ovary (10) T
A
95
5
TT
TA
AA
90
10
0
9
1
0
0.867 0.08
Thyroid (9) T
A
77.8
22.2
TT
TA
AA
55.6
44.4
0
5
4
0
0.391 0.00001
SNP
1913 C > T
rs571064657
Control (114) C
T
99.12
0.88
CC
CT
TT
98.25
1.75
0
112
2
0
0.924
  1. NCBI assigned new SNPs are highlited in bold
  2. AF allele frequency, GF genotype frequency, HWE Hardy–Weinberg equilibrium