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Fig. 2 | BMC Research Notes

Fig. 2

From: Cardiac regeneration in the axolotl is unaffected by alterations in leukocyte numbers induced by lipopolysaccharide and prednisolone

Fig. 2

Functional and anatomical cardiac regeneration is unaffected by pro- and anti-inflammatory stimulation. Echocardiography was performed every five days (both pre- and post-infarction on day 0) and hearts were harvested at day 40 for stereology. a Healed fraction of infarction relative to maximum infarction size at five days after injury. b Stroke volume pre-infarction at day -5 and 0 and thereafter post-infarction. c Cardiac output pre-infarction at day -5 and 0 and thereafter post-infarction. Significant differences in combined group shown by asterisks in b and c (black indicating significant difference to day 0 pre-infarction, green to day 5 at maximum infarction). d Representative color Doppler images at day 5 and day 40 post injury. Red color indicates blood flow towards transducer (ventral), blue away from transducer (dorsal), and lack of color indicates no blood flow. Infarction area is identified by a lack of blood flow due non-functioning cardiac muscle, and it is highlighted by yellow dashed line. All images were captured at end diastole. e Infarction fractions at day 40 measured by quantitative histology using unbiased stereology and representative images of Masson’s-trichrome stained hearts at day 40 from control, LPS and prednisolone animals with remaining infarction indicated by red dashed line. Error bars on all panels represent 95% confidence interval

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