Maternal Characteristic | No folic acid supplementation | Folic acid supplementation | p-value |
---|---|---|---|
Supplemented with multiple micronutrients (all of which contained folic acid) | 0 yes 198 no | 526 yes 250 no | < 0.001 |
Age (years) | 33.1 (32.5–33.7) (n = 179) | 33.6 (33.3–33.9) (n = 710) | 0.2 |
Height (m) | 1.65 (1.64–1.66) (n = 180) | 1.66 (1.66–1.67) (n = 729) | 0.2 |
Pre-pregnancy weight (kg) | 67.0 (65.0–69.0) (n = 177) | 66.1 (65.1–67.1) (n = 708) | 0.4 |
Weight gain in pregnancy (kg) | 7.5 (6.3–8.6) (n = 121) | 8.7 (8.2–9.3) (n = 523) | 0.1 |
Pre-pregnancy BMI (kg/m2) | 24.5 (23.9–25.2) (n = 172) | 24.0 (23.6–24.3) (n = 693) | 0.1 |
Smoked during pregnancy | 11 yes 184 no | 20 yes 742 no | 0.03 |
Parity (n of pregnancies) | 2.0 (1.9–2.1) (n = 195) | 1.7 (1.6–1.8) (n = 761) | < 0.001 |
Anaemia | 3 yes 183 no | 19 yes 717 no | 0.6 |
GDM | 11 yes 112 no | 57 yes 489 no | 0.6 |
Pre-eclampsia | 3 yes 195 no | 12 yes 764 no | 1.0 |
Gestational hypertension | 7 yes 78 no | 21 yes 366 no | 0.3 |
Premature birth (< 37 weeks gestation) | 3 yes 192 no | 14 yes 748 no | 1.0 |
Length of pregnancy (weeks) | 39.9 (39.7–40.1) (n = 195) | 39.9 (39.8–40.0) (n = 762) | 1.0 |
Offspring low birth weight | 5 yes 190 no | 21 yes 739 no | 0.9 |
Offspring SGA at birth (n no/yes) | 0 yes 195 no | 5 yes 755 no | 0.6 |