Table 2 Logistic regression analysis for the association between CYP21A2 polymorphisms and prevalent late-life depression (LLD)^a in the whole sample and according to sex

rs389883, n

733

252

327

68

406

184

AA

64.26

58.73

–

–

61.47

63.24

–

–

66.50

57.07

AC + CC

35.74

41.27

1.32 [0.98; 1.77]

0.07

38.53

36.76

0.98 [0.57; 1.69]

0.94

33.50

42.93

1.51 [1.05; 2.16]

0.025

rs437179, n

739

251

331

65

408

186

GG

64.28

58.57

–

–

60.42

64.62

–

–

67.40

56.45

GT + TT

35.72

41.43

1.34 [0.99; 1.80]

0.056

39.58

35.38

0.87 [0.50; 1.52]

0.63

32.60

43.55

1.61 [1.13; 2.30]

0.009

rs429608, n

722

251

326

65

396

186

GG

67.73

69.32

–

–

66.87

73.85

–

–

68.43

67.74

AG + AA

32.27

30.68

0.93 [0.68; 1.27]

0.64

33.13

26.15

0.70 [0.38; 1.28]

0.25

31.57

32.26

1.03 [0.71; 1.50]

0.86

rs438999, n

746

255

335

68

411

187

TT

77.08

78.43

–

–

77.61

79.41

–

–

76.64

78.07

CT + CC

22.92

21.57

0.92 [0.65; 1.30]

0.64

22.39

20.59

0.87 [0.45; 1.65]

0.66

23.36

21.93

0.93 [0.61; 1.41]

0.73

rs630379, n

746

254

336

67

410

187

GG

65.28

59.06

–

–

61.90

67.16

–

–

68.05

56.15

GT + TT

34.72

40.94

1.35 [1.00; 1.82]

0.047

38.10

32.84

0.82 [0.47; 1.44]

0.49

31.95

43.85

1.68 [1.17; 2.40]

0.0045