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Table 2 Crude and adjusted odds ratio of latent TB infection among BATT study participants, Atlanta, Georgia 2016–2019 (N  =  132)

From: Latent tuberculosis infection among patients with and without type-2 diabetes mellitus: results from a hospital case-control study in Atlanta

Characteristics

LTBI status

Total N  =  132

cOR (95% CI)

aOR (95% CI)

Negative N (%)  =  118 (89.4)

Positive N (%)  =  14 (10.6)

Group

 Controls

29 (85.3)

5 (14.7)

34 (25.8)

Reference

Reference

 Cases (T2DM)

89 (90.8)

9 (9.2)

98 (74.2)

0.59 (0.19–2.04)

0.45 (0.13–1.71)

Age group

 21–40

19 (95.0)

1 (5.0)

20 (15.2)

0.59 (0.03–3.59)

0.40 (0.02–2.75)

 41–60

78 (91.8)

7 (8.2)

85 (64.4)

Reference

Reference

 > 60

21 (77.8)

6 (22.2)

27 (20.5)

3.18 (0.94–10.61)

3.09 (0.89–10.44)

Gender

 Male

52 (88.1)

7 (11.9)

59 (44.7)

Reference

Reference

 Female

66 (90.4)

5 (9.6)

73 (55.3)

0.79 (0.26–2.44)

1.09 (0.34–3.48)

Race/ethnicity

 Non-hispanic black

105 (89.0)

13 (11.0)

118 (89.4)

1.6 (0.28–30.4)

 

 Other

13 (92.9)

1 (7.1)

14 (10.6)

Reference

 

Highest education

 Less than high school

22 (84.6)

4 (15.4)

26 (19.7)

Reference

 

 High school graduate

70 (93.3)

5 (6.7)

75 (56.8)

0.39 (0.10–1.71)

 

 College/university

21 (80.8)

5 (19.2)

26 (19.7)

1.31 (0.31–5.93)

 

 Graduate school

5 (100.0)

0 (0.0)

5 (3.8)

N/A

 

Ever lived with TB-sick person

 No

110 (90.2)

12 (9.8)

122 (94.6)

Reference

 

 Yes

5 (71.4)

2 (28.6)

7 (5.4)

3.67 (0.49–19.20)

 

 Not sure

3

0

3

  

Currently on metformin, among cases (N  =  98)

 No

23 (85.2)

4 (14.8)

27 (27.8)

Reference

 

 Yes

65 (92.9)

5 (7.1)

70 (72.2)

0.44 (0.11–1.92)

 

 Missing

1

0

1

  

Current smoking

 No

76 (90.5)

8 (9.5)

84 (64.1)

Reference

 

 Yes

41 (87.2)

6 (12.8)

47 (35.9)

1.39 (0.43–4.27)

 

 Missing

1

1

2

  

Past smoking

 No

44 (97.8)

1 (2.2)

45 (34.1)

Reference

 

 Yes

74 (85.1)

13 (14.9)

87 (65.9)

7.73 (1.46–142.75)

 

Alcohol consumption

 Never

75 (90.4)

8 (9.6)

83 (62.9)

Reference

 

 Moderate

32 (86.5)

5 (13.5)

37 (28.0)

1.47 (0.42–4.74)

 

 Frequent

11 (91.7)

1 (8.3)

12 (9.1)

0.85 (0.04–5.34)

 

Ever diagnosed with high cholesterol level

 No

50 (87.7)

7 (12.3)

57 (45.2)

Reference

 

 Yes

62 (89.9)

7 (10.1)

69 (54.8)

0.81 (0.26–2.50)

 

 Not sure

6

0

6

  

Ever diagnosed with high blood pressure

 No

47 (94.0)

3 (6.0)

50 (38.5)

Reference

 

 Yes

69 (86.3)

11 (13.8)

80 (61.5)

2.50 (0.73–11.48)

 

 Not sure

2

0

2

  

Ever diagnosed with heart disease

 No

101 (89.4)

12 (10.6)

113 (87.6)

Reference

 

 Yes

14 (87.5)

2 (12.5)

16 (12.4)

1.20 (0.18–5.05)

 

 Not sure

3

0

3

  

Ever diagnosed with liver disease

 No

109 (89.3)

13 (10.7)

122 (96.1)

Reference

 

 Yes

4 (80.0)

1 (20.0)

5 (3.9)

2.10 (0.10–15.57)

 

 Not sure

5

0

5

  

Ever diagnosed with kidney disease

 No

108 (88.5)

14 (11.5)

122 (94.6)

Reference

 

 Yes

7 (100.0)

0 (0.0)

7 (5.4)

N/A

 

 Not sure

3

0

3

  

Family members with T2DM

 No

29 (80.6)

7 (19.4)

36 (27.3)

Reference

 

 Yes

89 (92.7)

7 (7.3)

96 (72.7)

0.33 (0.10–1.03)

 

BMI

 Normal (18.5–25)

19 (82.6)

4 (17.4)

23 (17.4)

Reference

 

 Underweight (<  18.5)

3 (100.0)

0 (0.0)

3 (2.3)

N/A

 

 Overweight (25–30)

28 (96.6)

1 (3.5)

29 (22.0)

0.17 (0.01–1.26)

 

 Obese (≥  30)

68 (88.3)

9 (11.7)

77 (58.3)

0.63 (0.18–2.52)

 

Glycated hemoglobin level

 Median (IQR)

6.7 (5.6–8.6)

6.0 (5.3–9.2)

6.7 (5.6–8.7)

  
  1. aOR adjusted odds ratio; BMI body mass index; CI confidence interval; cOR crude odds ratio; T2DM type-2 diabetes mellitus; IQR interquartile range