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Table 1 Pharmacokinetic parameters (mean ± SEM) after single intraperitoneal/oral dose of three (1, 2 & 3) chalcone derivatives

From: Pharmacokinetic evaluation of Chalcone derivatives with antimalarial activity in New Zealand White Rabbits

Pharmacokinetic Parameters Derivative 1
(mean ± SEM)
Derivative 2
(mean ± SEM)
Derivative 3
(mean ± SEM)
Administered Dose (mg/1.5 kg Rabbits) 5.46 7.28 5.46
Administration Route Intraperitoneal Oral Oral
C0 (µg/mL) 0.966 ± 0.025 0.986 ± 0.004 0.944 ± 0.007
Cmax (µg/mL) 1.96 ± 0.46 69.89 ± 5.49 3.74 ± 1.64
tmax (h) 0.33 ± 0.05 3.4 ± 0.79 2.83 ± 0.87
t1/2 (h) 12.60 ± 2.09 93.32 ± 32.59 13.30 ± 1.67
AUC0–48 (µg.h/mL) 2.94 ± 0.83 3755.16 ± 738.71 14.16 ± 3.78
Ke − 0.035 ± 0.026 − 0.013 ± 0.004 − 0.056 ± 0.007
CL (mL/min) 0.28 ± 0.08 0.15 ± 0.05 0.53 ± 0.10
Vd (L) 7.31 ± 0.29 10.72 ± 0.66 9.12 ± 0.73
  1. C0 Concentration of administrated drug at time zero, Cmax Peak plasma concentration, tmax time to reach the peak plasma concentration, t1/2 elimination half-life, AUC Area under the total plasma concentration–time curve, Ke Elimination rate constant, CL Plasma clearance, Vd Volume of distribution