Table 1 Pharmacokinetic parameters (mean ± SEM) after single intraperitoneal/oral dose of three (1, 2 & 3) chalcone derivatives
Pharmacokinetic Parameters | Derivative 1 (mean ± SEM) | Derivative 2 (mean ± SEM) | Derivative 3 (mean ± SEM) |
|---|---|---|---|
Administered Dose (mg/1.5 kg Rabbits) | 5.46 | 7.28 | 5.46 |
Administration Route | Intraperitoneal | Oral | Oral |
C0 (µg/mL) | 0.966 ± 0.025 | 0.986 ± 0.004 | 0.944 ± 0.007 |
Cmax (µg/mL) | 1.96 ± 0.46 | 69.89 ± 5.49 | 3.74 ± 1.64 |
tmax (h) | 0.33 ± 0.05 | 3.4 ± 0.79 | 2.83 ± 0.87 |
t1/2 (h) | 12.60 ± 2.09 | 93.32 ± 32.59 | 13.30 ± 1.67 |
AUC0–48 (µg.h/mL) | 2.94 ± 0.83 | 3755.16 ± 738.71 | 14.16 ± 3.78 |
Ke | − 0.035 ± 0.026 | − 0.013 ± 0.004 | − 0.056 ± 0.007 |
CL (mL/min) | 0.28 ± 0.08 | 0.15 ± 0.05 | 0.53 ± 0.10 |
Vd (L) | 7.31 ± 0.29 | 10.72 ± 0.66 | 9.12 ± 0.73 |