Table 1 Significant association observed between GRIN2B and phenotypes related to depression for certain cohorts (left part) and the number of case and control for all the cohorts (All, Male, Female) (right part). The cells enclosed by a thick line correspond to the cohort shown in the left part for which significant association is found
No | Question | Case (Definition) | Control (Definition) | Cohort | No. of associated SNPs | SNPs with the lowest p-value | P-value | OR | All Cohort | Male Cohort | Female Cohort | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case (N) | Control (N) | Case (N) | Control (N) | Case (N) | Control (N) | |||||||||
1a | Did you feel nervous? | Always Often Sometimes Rarely | Never | Male | 22 | rs11055680 | 1.13 × 10–5 | 0.853 (0.794–0.916) | 5,849 | 6,795 | 2,626 | 4,072 | 3,214 | 2,723 |
b | Did you feel nervous? | Always Often Sometimes | Rarely Never | Male | 12 | rs10845862 | 5.14 × 10–5 | 0.801 (0.719–0.891) | 2,106 | 10,538 | 897 | 5,801 | 1,200 | 4,737 |
2 | Did you feel you were a worthless person? | Always | Often Sometimes Rarely Never | Male | 23 | rs7970022 | 2.62 × 10–5 | 0.493 (0.355–0.686) | 387 | 12,257 | 158 | 6,540 | 220 | 5,717 |
3 | Did you feel uninterested in the things or could not really enjoy the things for the past one month? | Yes | No | Male | 65 | rs759619 | 8.51 × 10–7 | 1.21 (1.12–1.31) | 3,819 | 8,825 | 1,948 | 4,747 | 1,871 | 4,066 |
4 | Did you have a history of depression? | Yes | No | All | 2 | rs4763360 | 7.34 × 10–5 | 1.23 (1.11–1.35) | 1,061 | 11,583 | 545 | 6,153 | 516 | 5,421 |