Parameter Mean (SD) | Baseline | 1Â h | 2Â h | 4Â h | 6Â h | 8Â h |
---|---|---|---|---|---|---|
HR [bpm] | ||||||
 Sham | 79 (8) | 79 (13) | 75 (12) | 92 (9) | 86 (11) | 83 (15) |
 Histone it | 74 (18) | 79 (28) | 71 (16) | 91 (24) | 88 (22) | 85 (21) |
MAP [mmHg] | ||||||
 Sham | 71 (5) | 84 (7) | 84 (7) | 80 (7) | 75 (8) | 75 (12) |
 Histone it | 65 (10) | 77 (10) | 74 (12) | 77 (8) | 72 (9) | 78 (13) |
CVP [mmHg] | ||||||
 Sham | 8 (2) | 9 (4) | 10 (3) | 11 (4) | 9 (3) | 10 (3) |
 Histone it | 6 (2) | 9 (2) | 9 (1) | 9 (1) | 8 (1) | 8 (2) |
PAP [mmHg] | ||||||
 Sham | 28 (9) | 33 (5)* | 35 (7)* | 33 (6)* | 29 (4)* | 30 (8)* |
 Histone it | 18 (4) | 23 (8) | 27 (7)* | 28 (6)* | 23 (5) | 26 (6) |
CI [(l/min)/m2] | ||||||
 Sham | 3.5 (0.8) | 3.5 (0.7) | 3.4 (0.3) | 3.6 (0.4) | 3.9 (0.5)* | 3.6 (0.5)* |
 Histone it | 2.9 (0.8) | 2.8 (0.4) | 3.0 (0.5) | 3.5 (0.5) | 3.9 (0.5)* | 3.8 (0.5)* |
NE [mg/h] | ||||||
 Sham | 0 | 0.06 (0.15) | 0 | 0 | 0 | 0 |
 Histone it | 0 | 0.1 (0.19) | 0.27 (0.49) | 0.14 (0.38) | 0.14 (0.38) | 0.14 (0.38) |
T [°C] | ||||||
 Sham | 36.7 (0.8) | 37.5 (0.6) | 37.6 (0.4) | 37.7 (0.5) | 37.9 (0.5) | 37.7 (0.2) |
 Histone it | 35.8 (0.7) | 36.7 (0.8) | 36.8 (0.6) | 37.6 (0.6) | 37.7 (0.5) | 37.7(0.8) |
FRC [ml] | ||||||
 Sham | 662 (105) | 452 (104)* | 428 (103)* | 389 (107)* | 464 (66)* | 496 (44)* |
 Histone it | 772 (197) | 501 (158)* | 535 (172)* | 471 (98)* | 463 (107)* | 468 (103)* |
Lactate [mmol/l] | ||||||
Sham | 1.8 (1.2) | 1.58 (0.49) | 1.29 (0.39) | 0.79 (0.31) | 0.5 (0.09) | 0.5 (0.22) |
Histone it | 1.3 (0.53) | 1.56 (0.47) | 1.57 (0.61) | 0.99 (0.3) | 0.67 (0.16) | 0.7 (0.31) |
SvO2 [%] | ||||||
Sham | 67 (7) | 55 (9) | 54 (9) | 54 (16) | 55 (6) | 50 (10) |
Histone it | 67 (8) | 50 (13) | 53 (13) | 60 (10) | 56 (9) | 52 (9) |