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Table 1 Collected data on haemodynamic parameters, respiratory measurements and blood gas analyses

From: Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

Parameter
Mean (SD)
Baseline 1 h 2 h 4 h 6 h 8 h
HR [bpm]
 Sham 79 (8) 79 (13) 75 (12) 92 (9) 86 (11) 83 (15)
 Histone it 74 (18) 79 (28) 71 (16) 91 (24) 88 (22) 85 (21)
MAP [mmHg]
 Sham 71 (5) 84 (7) 84 (7) 80 (7) 75 (8) 75 (12)
 Histone it 65 (10) 77 (10) 74 (12) 77 (8) 72 (9) 78 (13)
CVP [mmHg]
 Sham 8 (2) 9 (4) 10 (3) 11 (4) 9 (3) 10 (3)
 Histone it 6 (2) 9 (2) 9 (1) 9 (1) 8 (1) 8 (2)
PAP [mmHg]
 Sham 28 (9) 33 (5)* 35 (7)* 33 (6)* 29 (4)* 30 (8)*
 Histone it 18 (4) 23 (8) 27 (7)* 28 (6)* 23 (5) 26 (6)
CI [(l/min)/m2]
 Sham 3.5 (0.8) 3.5 (0.7) 3.4 (0.3) 3.6 (0.4) 3.9 (0.5)* 3.6 (0.5)*
 Histone it 2.9 (0.8) 2.8 (0.4) 3.0 (0.5) 3.5 (0.5) 3.9 (0.5)* 3.8 (0.5)*
NE [mg/h]
 Sham 0 0.06 (0.15) 0 0 0 0
 Histone it 0 0.1 (0.19) 0.27 (0.49) 0.14 (0.38) 0.14 (0.38) 0.14 (0.38)
T [°C]
 Sham 36.7 (0.8) 37.5 (0.6) 37.6 (0.4) 37.7 (0.5) 37.9 (0.5) 37.7 (0.2)
 Histone it 35.8 (0.7) 36.7 (0.8) 36.8 (0.6) 37.6 (0.6) 37.7 (0.5) 37.7(0.8)
FRC [ml]
 Sham 662 (105) 452 (104)* 428 (103)* 389 (107)* 464 (66)* 496 (44)*
 Histone it 772 (197) 501 (158)* 535 (172)* 471 (98)* 463 (107)* 468 (103)*
Lactate [mmol/l]
Sham 1.8 (1.2) 1.58 (0.49) 1.29 (0.39) 0.79 (0.31) 0.5 (0.09) 0.5 (0.22)
Histone it 1.3 (0.53) 1.56 (0.47) 1.57 (0.61) 0.99 (0.3) 0.67 (0.16) 0.7 (0.31)
SvO2 [%]
Sham 67 (7) 55 (9) 54 (9) 54 (16) 55 (6) 50 (10)
Histone it 67 (8) 50 (13) 53 (13) 60 (10) 56 (9) 52 (9)
  1. HR: heart rate; MAP: mean arterial pressure; CVP: central venous pressure; PAP: pulmonary arterial pressure; NE: norepinephrine; CI: cardiac index; T: temperature; FRC: functional residual capacity; SvO2: central venous oxygen saturation; it: intratracheal