Table 1 Associations between the PCSK9 rs615563 variant and, FBS, lipid homeostasis variables and liver enzyme levels in 500 non-diabetic participants
From: Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes
Clinical data | N | Mean/median data level by rs615563 genotype | p value | Adjusted p-valuea | ||
|---|---|---|---|---|---|---|
GG | GA | AA | ||||
Sex (M/F) | 197/303 | 105/165 38.9 / 61.1% | 67/116 36.6 / 63.4% | 25/22 53.2 / 46.8% | - | - |
Age (years) | 499 | 41.52 ± 14.97 | 39.34 ± 14.96 | 40.09 ± 12.37 | 0.296 | - |
BMI (kg/m2) | 495 | 26.39 ± 14.7 | 27.18 15.62 ± | 27.10 ± 18.83 | 0.380 | - |
FBS (mg/dl) (IQR) | 500 | 92 (85–100) | 92 (85–98) | 92 (82–99) | 0.649 | 0.72 |
TC (mg/dL) | 500 | 184.07 ± 38.04 | 181.53 ± 38.15 | 185.80 ± 36.97 | 0.701 | 0.8 |
HDL-C (mg/dL) | 500 | 46.72 ± 10.23 | 46.77 ± 9.09 | 45.60 ± 9.47 | 0.745 | 0.96 |
Non-HDL (mg/dL) | 500 | 136.06 ± 35.24 | 133.18 ± 35.59 | 139.53 ± 37.55 | 0.488 | 0.66 |
LDL-C (mg/dL) | 500 | 107.70 ± 33.45 | 105.40 ± 36.80 | 108.27 ± 13 | 0.760 | 0.81 |
TG (mg/dl) (IQR) | 500 | 115 (78.5–163) | 103 (72–146) | 119 (72–195) | 0.137 | 0.36 |
ALT (U/I) (IQR) | 428 | 12 (9–17.75) | 13 (9–18) | 12 (8–15) | 0.465 | 0.7 |
AST (U/I) (IQR) | 428 | 27.5 (23–35) | 28 (23–34) | 0.894 | 0.64 | |