Fig. 3
From: Rapid spheroid assays in a 3-dimensional cell culture chip
The effect of combination of cisplatin and paynantheine on the growth and invasion of HK-1 spheroids. Spheroids embedded in the 24-well plate and in the 3D chip were treated with combination of cisplatin and paynantheine at high concentrations. a The drug combination inhibited the growth and invasion of the spheroid in the 24-well plate. Images were masked using Image J to show clarity of the growth and invasion of the spheroids. Image crop factor: 900 × 900. Images were resized to 120 × 102 pt on Adobe Illustrator. (Size bar: 200 μm). b The drug combination inhibited the growth and invasion of the spheroid in the 3D chip. Images were masked using Image J to show clarity of the growth and invasion of the spheroids. Image crop factor: 798 × 900. Images were resized to 120 × 140 pt on Adobe Illustrator. (Size bar: 200 μm)