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Table 2 Echocardiography measurements 28 days after MCT injection

From: Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension

 

C

MCT

RARW

MCT + RARW

Heart rate (bpm)

414 ± 26

362 ± 22

415 ± 39

397 ± 18

Left ventricle

 IVS, diastole (mm)

1.75 ± 0.08

1.56 ± 0.23

1.61 ± 0.06

1.59 ± 0.09

 IVS, systole (mm)

3.08 ± 0.14

2.85 ± 0.30

2.82 ± 0.07

2.75 ± 0.27

 LVID, diastole (mm)

8.28 ± 0.32

7.90 ± 0.32

8.19 ± 0.29

8.12 ± 0.34

 LVID, systole (mm)

4.98 ± 0.41

4.86 ± 0.46

5.02 ± 0.27

4.80 ± 0.37

 LVPW, diastole (mm)

1.79 ± 0.16

1.79 ± 0.16

1.81 ± 0.12

1.73 ± 0.09

 LVPW, systole (mm)

2.76 ± 0.28

2.78 ± 0.20

2.84 ± 0.21

2.66 ± 0.15

 Shortening fraction (%)

40 ± 3

35 ± 8

37 ± 2

44 ± 3

 Ejection fraction (%)

67 ± 4

68 ± 5

67 ± 2

72 ± 3

Mitral flow

 Peak E (m/s)

1143 ± 178

979 ± 89

1127 ± 97

1080 ± 57

 Peak A (m/s)

1040 ± 193

871 ± 53

855 ± 79

987 ± 71

 E/A ratio

1.1 ± 0.1

1.1 ± 0.2

1.3 ± 0.1

1.1 ± 0.1

Pulmonary artery flow

 PAAT (m/s)

23.43 ± 1.64

13.95 ± 0.95*

22.14 ± 1.40

18.93 ± 1.80*,†

 PAAT/Ejection time

0.32 ± 0.02

0.18 ± 0.02*

0.34 ± 0.02

0.25 ± 0.03

 Peak velocity (m/s)

1235 ± 71

978 ± 62*

1218 ± 54

1111 ± 32

 VTI (mm)

56 ± 2

36 ± 5*

53 ± 2

46 ± 2

  1. Rats consumed wine for 7 days before and 28 days after being injected with PAH-inducing MCT
  2. Values are mean ± S.E.M
  3. C Control, MCT Monocrotaline, RARW Reduced-alcohol red wine, bpm Heart rate, IVS inter-ventricular septum, LVID left ventricle internal diameter (mm) , LVPW left ventricle posterior wall, (mm), Peak E maximum velocity of mitral E wave (m/s), Peak A maximum velocity of mitral A wave (m/s), PAAT pulmonary artery acceleration time (m/s), VTI velocity time integral (mm)
  4. *p < 0.05 (vs C); p < 0.05 (vs MCT); n ≥ 5 per group