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Table 1 Coefficient of variation ratios [= female CV/(female CV + male CV)] of blood parameter data sets submitted to the Mouse Phenome Database (https://phenome.jax.org)

From: Analysis of the sex-specific variability of blood parameters in data sets of the Mouse Phenome Database

Parameter n ≥ 5/sex n ≥ 10/sex
Mean
CV ratio ± SD
CV ratio > 0.5: % (n) CV ratio < 0.5: % (n) Range of CV ratio (min–max) n mice (f + m) n of project data sets Mean
CV ratio ± SD
CV ratio > 0.5: % (n) CV ratio < 0.5: % (n) Range of CV ratio (min–max) n mice (f + m) n of project data sets
Cholesterol 0.52 ± 0.11 66% (220) 34% (111) 0.13–0.82 6461 17 0.51 ± 0.11 58% (62) 42% (44) 0.21–0.79 3198 12
Creatinine 0.48 ± 0.10 50% (6) 50% (6) 0.23–0.65 482 4 0.498 ± 0.07 44% (4) 56% (5) 0.40–0.65 424 3
Glucose 0.51 ± 0.10 56% (142) 44% (110) 0.21–0.93 4657 17 0.51 ± 0.07 58% (31) 42% (22) 0.36–0.69 1949 9
Total protein 0.49 ± 0.08 41% (48) 59% (70) 0.24–0.73 2760 9 0.496 ± 0.08 49% (23) 51% (24) 0.31–0.72 1555 6
Triglycerides 0.51 ± 0.11 56% (163) 44% (126) 0.15–0.86 5654 16 0.51 ± 0.10 56% (57) 44% (44) 0.25–0.74 2922 10
Urea 0.52 ± 0.09 64% (112) 36% (64) 0.19–0.82 3726 12 0.51 ± 0.10 59% (29) 41% (20) 0.23–0.73 1750 8
Uric acid 0.49 ± 0.11 45% (21) 55% (26) 0.29–0.73 989 3 0.48 ± 0.09 40% (6) 60% (9) 0.35–0.63 403 3
Ferritin 0.53 ± 0.07 75% (3) 25% (1) 0.43–0.58 119 1 0.53 ± 0.07 75% (3) 25% (1) 0.43–0.58 119 1
Transferrin 0.46 ± 0.06 25% (1) 75% (3) 0.38–0.51 119 1 0.46 ± 0.06 25% (1) 75% (3) 0.38–0.51 119 1
Calcium 0.497 ± 0.11 48% (80) 52% (86) 0.22–0.84 3644 12 0.49 ± 0.11 45% (33) 55% (40) 0.28–0.78 2101 8
Chloride 0.51 ± 0.10 57% (66) 43% (50) 0.20–0.86 2346 7 0.46 ± 0.16 40% (6) 60% (9) 0.20–0.86 783 4
Phosphorus 0.51 ± 0.08 54% (62) 46% (53) 0.21–0.72 2651 9 0.49 ± 0.08 46% (21) 54% (25) 0.32–0.71 1474 6
Potassium 0.51 ± 0.07 60% (70) 40% (47) 0.17–0.68 2307 7 0.51 ± 0.07 55% (6) 45% (5) 0.42–0.64 682 4
Sodium 0.51 ± 0.10 62% (73) 38% (44) 0.20–0.79 2308 7 0.48 ± 0.14 33% (4) 67% (8) 0.21–0.79 712 4
ALT 0.44 ± 0.11 24% (5) 76% (16) 0.25–0.70 416 5 0.39 ± 0.11 10% (1) 90% (9) 0.25–0.56 265 3
AST 0.49 ± 0.08 47% (30) 53% (34) 0.20–0.71 1319 6 0.49 ± 0.08 50% (10) 50% (10) 0.32–0.60 540 4
α-Amylase 0.51 ± 0.09 55% (32) 45% (26) 0.28–0.67 1251 3 0.51 ± 0.11 46% (11) 54% (13) 0.28–0.67 610 3
AP 0.496 ± 0.10 46% (43) 54% (50) 0.24–0.78 1955 7 0.51 ± 0.08 59% (16) 41% (11) 0.37–0.76 825 4
CK           
Lipase 0.49 ± 0.13 41% (9) 59% (13) 0.30–0.76 347 1      
Hemoglobin 0.48 ± 0.12 47% (159) 53% (177) 0.07–0.88 6774 16 0.48 ± 0.11 46% (57) 54% (68) 0.14–0.88 3721 11
MCV 0.49 ± 0.12 55% (183) 45% (149) 0.09–0.90 7075 16 0.496 ± 0.12 57% (69) 43% (52) 0.09–0.80 4031 11
RBC 0.49 ± 0.11 49% (154) 51% (163) 0.08–0.85 6354 15 0.47 ± 0.10 36% (40) 64% (71) 0.27–0.78 3396 10
WBC 0.52 ± 0.10 60% (210) 40% (142) 0.18–0.86 7050 17 0.501 ± 0.08 56% (69) 44% (55) 0.28–0.72 3690 11
Platelets 0.51 ± 0.11 55% (183) 45% (150) 0.17–0.89 6732 16 0.49 ± 0.10 52% (64) 48% (60) 0.26–0.76 3703 11
  1. CV: coefficient of variation = standard deviation/mean; CV ratio: coefficient of variation ratio [= female CV/(female CV + male CV)]; SD: standard deviation. The values of the mean CV ratios are indicated in bold for the parameters where the female CV is higher than the male CV (i.e. a CV ratio > 0.5)
  2. “n ≥ 5/sex” and “n ≥ 10/sex”: data of “n ≥ 10/sex” is included in the data of “n ≥ 5/sex”. For each parameter, the number of strain data sets included in the analysis and showing a CV ratio > 0.5 and a CV ratio < 0.5 is given in parentheses behind the respective value in %. Exclusion of strain data sets was carried out where the female and/or the male group showed a CV > 0.5 for the respective parameter
  3. n of project data sets: the number of project data sets from which strain data sets were included in the analysis
  4. Parameters and their results are depicted in smaller characters in the case that less than 50 strain data sets were available for the analysis “n ≥ 5/sex”. This refers to the six parameters creatinine, uric acid, ferritin, transferrin, ALT and lipase
  5. The parameters chloride, phosphorus, sodium, AP and platelets and their mean CV ratios are indicated in italics as they showed inconsistent CV ratios in both analyses, i.e. a CV ratio > 0.5 in the analysis “n ≥ 5/sex” and a CV ratio < 0.5 in the analysis “n ≥ 10/sex” appeared; or vice versa
  6. ALT alanine aminotransferase (EC 2.6.1.2), AST aspartate aminotransferase (EC 2.6.1.1); α-amylase (EC 3.2.1.1), AP alkaline phosphatase (EC 3.1.3.1), CK creatine kinase (EC 2.7.3.2); lipase (EC 3.1.1.3), MCV mean corpuscular volume, RBC red blood cell count, WBC white blood cell count