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Table 2 Coefficient of variation ratios [= female CV/(female CV + male CV)] of blood parameter data sets of selected inbred strains submitted to the Mouse Phenome Database (https://phenome.jax.org)

From: Analysis of the sex-specific variability of blood parameters in data sets of the Mouse Phenome Database

Mean CV ratio ± SD (n of data sets) A/J… BALB/c… C3H… C57BL/6… CBA/… DBA/2J…
Cholesterol 0.56 ± 0.09 (9) 0.54 ± 0.05 (13) 0.53 ± 0.10 (10) 0.51 ± 0.13 (16) 0.51 ± 0.16 (8) 0.61 ± 0.12 (7)
Creatinine 0.49 ± 0.02 (2) 0.50 ± 0.06 (5) 0.48 ± 0.04 (3) 0.51 ± 0.08 (6) 0.53 ± 0.06 (3) 0.50 (1)
Glucose 0.60 ± 0.10 (7) 0.45 ± 0.12 (11) 0.52 ± 0.05 (8) 0.52 ± 0.09 (17) 0.48 ± 0.06 (6) 0.59 ± 0.10 (5)
Total protein 0.49 ± 0.04 (3) 0.50 ± 0.04 (9) 0.43 ± 0.11 (6) 0.50 ± 0.07 (7) 0.47 ± 0.04 (5) 0.55 ± 0.07 (4)
Triglycerides 0.55 ± 0.10 (9) 0.50 ± 0.14 (13) 0.54 ± 0.07 (10) 0.52 ± 0.16 (16) 0.55 ± 0.10 (8) 0.54 ± 0.12 (7)
Urea 0.50 ± 0.18 (5) 0.45 ± 0.11 (11) 0.56 ± 0.09 (8) 0.52 ± 0.12 (10) 0.54 ± 0.10 (6) 0.52 ± 0.15 (5)
Uric acid 0.44 (1) 0.48 ± 0.01 (4) 0.46 (1) 0.52 ± 0.10 (3) 0.55 ± 0.12 (3) 0.67 (1)
Ferritin 0.58 (1) 0.53 (1) 0.58 (1)
Transferrin 0.51 (1) 0.50 (1) 0.46 (1)
Calcium 0.49 ± 0.08 (5) 0.47 ± 0.11 (11) 0.49 ± 0.11 (8) 0.52 ± 0.08 (10) 0.47 ± 0.13 (6) 0.56 ± 0.13 (6)
Chloride 0.53 ± 0.06 (3) 0.61 ± 0.17 (4) 0.61 ± 0.18 (4) 0.51 ± 0.13 (5) 0.50 (1) 0.53 ± 0.06 (2)
Phosphorus 0.54 ± 0.05 (3) 0.46 ± 0.11 (9) 0.52 ± 0.07 (6) 0.53 ± 0.18 (7) 0.48 ± 0.08 (5) 0.48 ± 0.09 (4)
Potassium 0.54 ± 0.06 (3) 0.54 ± 0.04 (4) 0.50 ± 0.07 (4) 0.46 ± 0.04 (5) 0.53 (1) 0.47 ± 0.03 (2)
Sodium 0.48 ± 0.01 (3) 0.55 ± 0.05 (4) 0.64 ± 0.15 (4) 0.52 ± 0.10 (5) 0.51 (1) 0.46 ± 0.04 (2)
ALT 0.47 (1) 0.46 ± 0.08 (4) 0.41 ± 0.04 (3) 0.45 ± 0.09 (5) 0.40 ± 0.22 (2) 0.40 ± 0.11 (2)
AST 0.45 ± 0.21 (3) 0.54 ± 0.04 (4) 0.46 ± 0.01 (2) 0.42 ± 0.09 (5) 0.51 ± 0.01 (3) 0.47 (1)
α-Amylase 0.55 ± 0.05 (2) 0.54 ± 0.09 (4) 0.53 ± 0.06 (2) 0.50 ± 0.10 (4) 0.57 ± 0.02 (3) 0.34 (1)
AP 0.50 ± 0.04 (3) 0.56 ± 0.10 (5) 0.57 ± 0.19 (3) 0.53 ± 0.16 (5) 0.44 ± 0.00 (3) 0.53 ± 0.07 (2)
CK 0.52 ± 0.05 (4) 0.43 ± 0.10 (3) 0.52 ± 0.14 (3) 0.42 ± 0.22 (2) 0.39 ± 0.08 (2)
Lipase 0.44 (1) 0.58 (1) 0.40 (1) 0.43 (1)
Hemoglobin 0.51 ± 0.17 (10) 0.47 ± 0.12 (15) 0.46 ± 0.07 (10) 0.45 ± 0.08 (15) 0.50 ± 0.07 (9) 0.45 ± 0.08 (8)
MCV 0.56 ± 0.10 (10) 0.51 ± 0.14 (15) 0.49 ± 0.14 (10) 0.46 ± 0.08 (15) 0.51 ± 0.12 (11) 0.45 ± 0.13 (8)
RBC 0.52 ± 0.12 (9) 0.45 ± 0.12 (14) 0.49 ± 0.06 (9) 0.48 ± 0.09 (14) 0.52 ± 0.09 (10) 0.39 ± 0.11 (7)
WBC 0.51 ± 0.11 (11) 0.48 ± 0.11 (16) 0.45 ± 0.08 (11) 0.50 ± 0.10 (16) 0.53 ± 0.05 (11) 0.50 ± 0.07 (9)
Platelets 0.56 ± 0.14 (10) 0.47 ± 0.13 (15) 0.51 ± 0.11 (10) 0.49 ± 0.11 (15) 0.49 ± 0.10 (10) 0.47 ± 0.07 (8)
“n ≥ 5”: n CV ratio > 0.5 9 of 10 4 of 14 6 of 12 11 of 19 6 of 12 6 of 10
“n ≥ 1”: n CV ratio > 0.5 14 of 22 13 of 25 12 of 25 14 of 24 13 of 22 10 of 23
  1. CV: coefficient of variation = standard deviation/mean; CV ratio: coefficient of variation ratio [= female CV/(female CV + male CV)]; SD: standard deviation. The values of the mean CV ratios are indicated in bold for the parameters where the female CV is higher than the male CV (i.e. a CV ratio > 0.5). No exclusion of strain data sets was carried out in the case that the female and/or the male group showed a CV > 0.5 for the respective parameter
  2. Data sets with the designation A/J…, BALB/c…, C3H…, C57BL/6…, CBA/… and DBA/2J… were summarized for the respective inbred strains A/J, BALB/c, C3H, C57BL/6, CBA and DBA/2 J
  3. “n ≥ 5” and “n ≥ 1”: the number of data sets available for a given parameter of a selected inbred strain is shown in parentheses behind the value of the mean CV ratio ± SD. Results including less than five data sets are depicted in smaller characters. The analysis “n ≥ 5” exhibits the number of parameters with a CV ratio > 0.5 compared to the number of all parameters with at least five data sets. The analysis “n ≥ 1” exhibits the number of parameters with a CV ratio > 0.5 compared to the number of all parameters with at least one data set
  4. ALT alanine aminotransferase (EC 2.6.1.2), AST aspartate aminotransferase (EC 2.6.1.1); α-amylase (EC 3.2.1.1), AP alkaline phosphatase (EC 3.1.3.1), CK creatine kinase (EC 2.7.3.2); lipase (EC 3.1.1.3), MCV mean corpuscular volume, RBC red blood cell count, WBC white blood cell count