Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults

BMC Research Notes

Table 3 Intraclass correlation coefficients (ICC) and required measuring days based on baseline measurements

	Mean CV%	ICC	Days to obtain	Days to obtain	Days to obtain
	Mean CV%	ICC	ICC = 0.60	ICC = 0.70	ICC = 0.80
Cortisol
S1	31.9	0.41	2	3	6
CAR
CAR30 (30 min—S1)	75.3	0.17	3	4	7
CARpeak (Peak cortisol—S1)	52.3	0.17	2	3	5
CARauc	20.1	0.56	1	2	4
DCS
Wake-to-bed slope	59.7	0.35	3	4	7
Peak-to-bed slope	31.9	0.51	1	1	3
Cortisone
S1	17.1	0.28	4	6	10
CAR
CAR30 (30 min—S1)	49.0	0.29	4	6	10
CARpeak (Peak cortisol—S1)	44.8	0.60	1	2	3
CARauc	14.7	0.57	1	2	4
DCS
Wake-to-bed slope	37.5	0.18	7	11	18
Peak-to-bed slope	24.1	0.68	1	2	3

The table present the coefficient of variation (%) and intraclass correlation coefficient (ICC) for concentrations of cortisol and cortisone within the same participant at baseline and the required number of measuring days to obtain ICC values of 0.60, 0.70 and 0.80
S1 The salivary sample collected immediately upon awakening, CAR Cortisol (or cortisone) awakening response, CAR30 Difference between S1 and the salivary sample 30 min later, CARpeak Difference between S1 and the value of the second or third morning salivary sample, whichever was the largest; CARauc The area under the curve for the morning salivary samples, DCS Diurnal cortisol (or cortisone) slope

ISSN: 1756-0500