Fig. 1

Schematic representation of the NUDT15 gene with all known coding variants. The *2 to *20 alleles were reported in PharmVar. Arrows indicate PCR and sequencing primers (1F, 1R, 2F, 2R, 3F and 3R) flanking the three coding exons. Dotted vertical lines show alleles with two variants in cis. The *2 allele harbours two variants, namely c.55_56insGAGTCG (*6 in exon 1) and c.415C>T (*3 in exon 3). The *20 allele consists of c.386C>G in exon 3 and c.*7G>A in the 5′ unstranslated region. The c.97A>G and c.224T>G variants were reported in HGMD, but not in PharmVar [11]. HGVS, Human Genome Variation Society. Figure is not drawn to scale