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Table 2 Associations between FTO rs1421085, macronutrient intake, and dietary fatty acids intake in various genetic models

From: Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Genetic model

n

BMI (kg/m2)

Carb. intake (%)

Protein intake (%)

Fat intake (%)

PUFA intake (%)

MUFA intake (%)

SAFA intake (%)

Coef. (95% CI)

p

Coef. (95% CI)

p

Coef. (95% CI)

p

Coef. (95% CI)

p

Coef. (95% CI)

p

Coef. (95% CI)

p

Coef. (95% CI)

p

Co-dominant

TT

43

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

TC

25

0.47 (− 2.66–3.6)

0.766

− 0.70 (− 3.64–2.25)

0.639

0.27 (− 1.18–1.73)

0.709

3.87 (0.69–7.05)

0.018

0.45 (− 0.72–1.63)

0.444

1.13 (− 0.03–2.29)

0.055

1.77 (− 0.06–3.6)

0.058

CC

3

12.58 (5.15–20.01)

0.001

− 7.84 (− 14.84 to − 0.83)

0.029

0.77 (− 2.68–4.22)

0.657

5.63 (− 1.92–13.18)

0.141

0.84 (− 1.96–3.64)

0.551

1.27 (− 1.48–4.03)

0.360

4.49 (0.14–8.84)

0.043

Dominant

TT

43

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

TC + CC

28

0.70 (− 2.27–3.67)

0.640

− 1.47 (− 4.38–1.44)

0.316

0.35 (− 0.98–1.68)

0.602

4.06 (1.01–7.11)

0.010

0.54 (− 0.59–1.67)

0.341

1.14 (0.02–2.26)

0.046

2.06 (0.29–3.83)

0.023

Recessive

TT + TC

68

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

CC

3

12.38 (5.3–19.46)

< 0.001

− 7.59 (− 14.47–-0.71)

0.031

0.70 (− 2.7–4.1)

0.681

4.24 (− 3.48–11.97)

0.277

0.71 (− 1.97–3.39)

0.599

0.70 (− 2.31–3.71)

0.644

3.86 (− 0.53–8.24)

0.084

Over-dominant

TT + CC

46

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

TC

25

0.20 (− 2.84–3.25)

0.894

− 0.20 (− 3.2–2.8)

0.895

0.22 (− 1.24–1.68)

0.766

3.51 (0.34–6.68)

0.030

0.41 (− 0.73–1.54)

0.477

1.06 (− 0.14–2.26)

0.083

1.48 (− 0.37–3.33)

0.115

Additive

71

1.17 (− 1.38–3.72)

0.363

− 1.99 (− 4.42–0.45)

0.109

0.32 (− 0.84–1.48)

0.586

3.45 (0.86–6.04)

0.010

0.43 (− 0.51–1.38)

0.365

0.86 (− 0.1–1.82)

0.078

1.96 (0.47–3.45)

0.011

  1. BMI: Body Mass Index (kg/m2); Carb.: carbohydrate; PUFA: polyunsaturated fatty acid; MUFA: monounsaturated fatty acid; SAFA: saturated fatty acid; Coef.: regression coefficients; Ref.: indicate the reference genotype in a particular genetic model; p: p-values obtained through linear model analyses for normally distributed variables (carbohydrate, fat, and SAFA intake) or rank-based linear model analyses for non-normal variables (BMI, protein, PUFA, and MUFA); CI: confidence interval
  2. All analyses were adjusted for age and sex. Significant associations were marked in bold (p < 0.05)
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BMC Research Notes

ISSN: 1756-0500

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