Skip to main content

Table 2 Associations between FTO rs1421085, macronutrient intake, and dietary fatty acids intake in various genetic models

From: Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Genetic model n BMI (kg/m2) Carb. intake (%) Protein intake (%) Fat intake (%) PUFA intake (%) MUFA intake (%) SAFA intake (%)
Coef. (95% CI) p Coef. (95% CI) p Coef. (95% CI) p Coef. (95% CI) p Coef. (95% CI) p Coef. (95% CI) p Coef. (95% CI) p
Co-dominant
TT 43 Ref.   Ref.   Ref.   Ref.   Ref.   Ref.   Ref.  
TC 25 0.47 (− 2.66–3.6) 0.766 − 0.70 (− 3.64–2.25) 0.639 0.27 (− 1.18–1.73) 0.709 3.87 (0.69–7.05) 0.018 0.45 (− 0.72–1.63) 0.444 1.13 (− 0.03–2.29) 0.055 1.77 (− 0.06–3.6) 0.058
CC 3 12.58 (5.15–20.01) 0.001 − 7.84 (− 14.84 to − 0.83) 0.029 0.77 (− 2.68–4.22) 0.657 5.63 (− 1.92–13.18) 0.141 0.84 (− 1.96–3.64) 0.551 1.27 (− 1.48–4.03) 0.360 4.49 (0.14–8.84) 0.043
Dominant
TT 43 Ref.   Ref.   Ref.   Ref.   Ref.   Ref.   Ref.  
TC + CC 28 0.70 (− 2.27–3.67) 0.640 − 1.47 (− 4.38–1.44) 0.316 0.35 (− 0.98–1.68) 0.602 4.06 (1.01–7.11) 0.010 0.54 (− 0.59–1.67) 0.341 1.14 (0.02–2.26) 0.046 2.06 (0.29–3.83) 0.023
Recessive
TT + TC 68 Ref.   Ref.   Ref.   Ref.   Ref.   Ref.   Ref.  
CC 3 12.38 (5.3–19.46) < 0.001 − 7.59 (− 14.47–-0.71) 0.031 0.70 (− 2.7–4.1) 0.681 4.24 (− 3.48–11.97) 0.277 0.71 (− 1.97–3.39) 0.599 0.70 (− 2.31–3.71) 0.644 3.86 (− 0.53–8.24) 0.084
Over-dominant
TT + CC 46 Ref.   Ref.   Ref.   Ref.   Ref.   Ref.   Ref.  
TC 25 0.20 (− 2.84–3.25) 0.894 − 0.20 (− 3.2–2.8) 0.895 0.22 (− 1.24–1.68) 0.766 3.51 (0.34–6.68) 0.030 0.41 (− 0.73–1.54) 0.477 1.06 (− 0.14–2.26) 0.083 1.48 (− 0.37–3.33) 0.115
Additive 71 1.17 (− 1.38–3.72) 0.363 − 1.99 (− 4.42–0.45) 0.109 0.32 (− 0.84–1.48) 0.586 3.45 (0.86–6.04) 0.010 0.43 (− 0.51–1.38) 0.365 0.86 (− 0.1–1.82) 0.078 1.96 (0.47–3.45) 0.011
  1. BMI: Body Mass Index (kg/m2); Carb.: carbohydrate; PUFA: polyunsaturated fatty acid; MUFA: monounsaturated fatty acid; SAFA: saturated fatty acid; Coef.: regression coefficients; Ref.: indicate the reference genotype in a particular genetic model; p: p-values obtained through linear model analyses for normally distributed variables (carbohydrate, fat, and SAFA intake) or rank-based linear model analyses for non-normal variables (BMI, protein, PUFA, and MUFA); CI: confidence interval
  2. All analyses were adjusted for age and sex. Significant associations were marked in bold (p < 0.05)