RT-QuIC detection of pathological prion protein in subclinical goats following experimental oral transmission of L-type BSE

Table 1 General data of goats experimentally infected with bovine isolates of L-BSE and PrP^sc-associate seeding activity distribution revealed by RT-QuIC analyses in nervous and lymphoreticular systems of subclinical animals

ID	Inoculum	Route of infection	Breed	Sex	Genotype	Age* (mo)	SV (mo)	BH PrP^sc	PrP^sc peripheral distribution
G1	L-BSE	OS	Mixed Breed	F	240 P/P	6	74	+	LNs: retropharyngeal, submandibular, mesenteric; tonsil; thoracic medulla
G2	L-BSE	OS	Saanen	F	240 P/P	6	45	+	LNs: mesenteric, mediastinal, retropharyngeal, submandibular; tonsil; thoracic medulla
G3	L-BSE	OS	Saanen	F	240 P/P	6	65	+	LNs: submandibular, mesenteric; tonsil; lombar and sacral medulla
G4	L-BSE	OS	Saanen	F	240 P/P	6	60	+	LNs: submandibular, mesenteric, mediastinal, retropharyngeal; tonsil; thoracic medulla
G5	L-BSE	OS	Saanen	F	240 P/P	6	78	+	LNs: mesenteric, mediastinal; tonsil;
CTR +	L-BSE	IC	Saanen	F	240 P/P	6	41	+	CSF
CTR 1	None	-	Mixed Breed	F	240 P/P	6	41	−	Negative
CTR 2	None	-	Saanen	F	240 P/P	6	74	−	Negative

OS oral administration, IC intracranial, F Female, SV survival time, BH brainstem homogenate, LNs Lympho nodes; mo months, n. a. not available. *Age at inoculation time

ISSN: 1756-0500