Table 2 Combination index and drug interaction in HeLa cell line
From: Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro
Combination | IC50 of drug in combination (Mean ± SD) | Combination index at ED (Mean ± SD) | Drug interaction |
|---|---|---|---|
Fucoxanthin and cisplatin Combo 1 | 20.216 ± 1.577 | ED50: 6.810 ± 0.984 | Strong antagonism |
ED75: 2.497 ± 0.683 | Antagonism | ||
ED90: 0.999 ± 0.406 | Nearly additive | ||
ED95: 0.569 ± 0.285 | Synergism | ||
Fucoxanthin and cisplatin Combo 2 | 8.698 ± 0.526 | ED50: 2.961 ± 0.865 | Strong antagonism |
ED75: 1.027 ± 0.453 | Nearly additive | ||
ED90: 0.400 ± 0.247 | Synergism | ||
ED95: 0.226 ± 0.168 | Strong synergism | ||
Fucoxanthin and cisplatin Combo 3 | 2.583 ± 0.425 | ED50: 0.694 ± 0.188 | Synergism |
ED75: 0.410 ± 0.133 | Synergism | ||
ED90: 0.244 ± 0.092 | Strong synergism | ||
ED95: 0.171 ± 0.071 | Strong synergism | ||
Bixin and cisplatin Combo 1 | 37.564 ± 2.810 | ED50: 7.802 ± 0.971 | Strong antagonism |
ED75: 2.884 ± 0.546 | Antagonism | ||
ED90: 1.115 ± 0.272 | Slight antagonism | ||
ED95: 0.602 ± 0.167 | Synergism | ||
Bixin and cisplatin Combo 2 | 32.110 ± 4.154 | ED50: 4.196 ± 1.007 | Strong antagonism |
ED75: 2.229 ± 0.582 | Antagonism | ||
ED90: 1.267 ± 0.420 | Moderate antagonism | ||
ED95: 0.897 ± 0.370 | Slight synergism | ||
Bixin and cisplatin Combo 3 | 31.303 ± 0.673 | ED50: 2.250 ± 0.547 | Antagonism |
ED75: 1.931 ± 0.133 | Antagonism | ||
ED90: 1.744 ± 0.442 | Antagonism | ||
ED95: 1.712 ± 0.704 | Antagonism |