Table 2 Characterization of prevalent SLE patients and their healthcare utilization across 4 US databases, 2016
CCAE | MDCR | OPTUM | MDCD | |
|---|---|---|---|---|
Total N | 28,846 | 4281 | 23,877 | 15,096 |
Women, n (%) | 26,476 (91.8) | 3759 (87.8) | 21,568 (90.3) | 13,979 (92.6) |
Mean age (SD), years | 47 (12) | 72 (7) | 56 (15) | 45 (15) |
Number of visits, median (interquartile range) | ||||
For any healthcare encounter | 17 (10–30) | 25 (15–41) | 20 (11–35) | 25 (13–49) |
With an SLE diagnosis | 4 (2–7) | 3 (2–5) | 4 (2–7) | 4 (2–8) |
Number of patients with ≥ 1 hospitalization, n (%) | 4374 (15.2) | 1185 (27.7) | 4510 (18.9) | 5044 (33.4) |
Median (interquartile range) length of hospital-stay, days | 3 (2–6) | 4 (2–8) | 4 (2–6) | 4 (2–6) |
Co-morbiditiesa, n (%) | ||||
Renal diseases | 5018 (17.4) | 1177 (27.5) | 6089 (25.5) | 4328 (28.7) |
Renal dialysis/failure | 2429 (8.4) | 902 (21.1) | 3970 (16.6) | 2781 (18.4) |
Cardiovascular diseases | ||||
Hypertension | 10,191 (35.3) | 2999 (70.1) | 11,457 (48.0) | 5218 (34.6) |
Ischemic heart disease | 1031 (3.6) | 545 (12.7) | 2186 (9.2) | 1433 (9.5) |
Heart failure | 903 (3.1) | 638 (14.9) | 2275 (9.5) | 2047 (13.6) |
Rheumatic heart disease | 483 (1.7) | 236 (5.5) | 799 (3.4) | 537 (3.6) |
Cerebral vascular diseases | 1052 (3.7) | 484 (11.3) | 1747 (7.3) | 1409 (9.3) |
Neuropsychiatric conditions | ||||
Headache (recorded on claims) | 4043 (14.0) | 512 (12.0) | 3804 (15.9) | 3897 (25.8) |
Psychosis | 444 (1.5) | 272 (6.4) | 990 (4.2) | 1004 (6.7) |
Epilepsy/seizure | 1050 (3.6) | 144 (3.4) | 1336 (5.6) | 1800 (11.9) |
Depression | 4112 (14.3) | 698 (16.3) | 4782 (20.0) | 3284 (21.8) |
Cutaneous manifestations | ||||
Cutaneous lupus | 4452 (15.4) | 683 (16.0) | 4133 (17.3) | 3136 (20.8) |
Dermatosis and dermatitis | 3977 (13.8) | 683 (16.0) | 3412 (14.3) | 2184 (14.5) |
Infections | 8778 (30.4) | 1450 (33.9) | 7955 (33.3) | 6405 (42.4) |
Hospitalized infections | 1543 (5.4) | 472 (11.0) | 1847 (7.7) | 2168 (14.4) |
Musculoskeletal comorbidities | ||||
Inflammatory Polyarthropathies | 6711 (23.3) | 1238 (28.9) | 7403 (31.0) | 3688 (24.4) |
Spondylopathies | 3050 (10.6) | 874 (20.4) | 3999 (16.8) | 2337 (15.5) |
Osteoarthritis | 7257 (25.2) | 2251 (52.6) | 9360 (39.2) | 5145 (34.1) |
Osteoporosis | 2351 (8.2) | 1056 (24.7) | 4051 (17.0) | 1257 (8.3) |
Medicationb use (any), n (%) | ||||
Anti-malarials | 18,129 (62.8) | 2275 (53.1) | 12,411 (52.0) | 5324 (35.3) |
Systemic corticosteroids | 18,518 (64.2) | 2768 (64.7) | 14,619 (61.2) | 9255 (61.3) |
Non-biologic disease modifying drugs | 5906 (20.5) | 660 (15.4) | 3904 (16.4) | 2423 (16.1) |
Biologics | 1286 (4.5) | 139 (3.2) | 818 (3.4) | 480 (3.2) |
Any of the above | 25,037 (86.8) | 3620 (84.6) | 19,268 (80.7) | 10,746 (71.2) |