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Table 2 Average number of deaths in the time period [465, 500] years and Kaplan–Meier estimates of the median survival time over the four simulation scenarios, over 1000 simulation runs in each scenario

From: Understanding bias when estimating life expectancy from age at death: a simulation approach applied to Morquio syndrome A

 

Scenario

1

2

3

4

Average number of deaths

 In [465, 500]

34.97

33.39

33.59

30.54

 Since 465

60.79

81.27

81.23

60.79

R

 Average KM estimates

 Died in [465, 500] (no censoring)

20.75

42.10

41.83

23.90

  Died since 465 (censored at 500)

29.84

60.16

59.95

33.78

  Died in [465, 500] (censored at 500, weighted by 0.1)

21.69

44.25

43.98

25.06

  Died in [465, 500] (censored at 500, weighted by uncensored percentage)

26.01

50.3

50.1

29.16

P

 Average number of deaths for individuals born since 465

  In [465, 500]

14.41

5.29

5.48

10.06

  Since 465

36

36

36

36

 Average KM estimates

  Born since 465 (censored at 500)

25.03

NA

NA

27.61

  1. R retrospective sampling (considering individuals who died since a certain year), P prospective sampling (considering individuals who were born after a certain year), NA estimation not possible due to small number of events