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Table 2 Genotype and allele frequency of XRCC1 and NBN genes polymorphisms and the association with childhood ALL

From: Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis

  Group P-Value OR 95% CI for OR
Control Patient Lower Upper
XRCC1 rs1799782 G > A
 Genotype
  GG 45 (48.9%) 47 (51.1%) 1
  GA 0 (0.0%) 0 (0.0%)
  AA 5 (62.5%) 3 (37.5%) 0.465 0.574 0.130 2.545
 Dominant model
  GA + AA 5 (62.5% 3 (37.5%) 0.465 0.574 0.130 2.545
 Recessive model
  GG + GA 45 (48.9%) 47 (51.1%) 0.465 1.74 0.393 7.713
 Allele
  G 90 (48.9%) 94 (51.1%) 1
  A 10 (62.5%) 6 (37.5%) 0.297 0.574 0.201 1.646
NBN rs709816 A > G
 Genotype
  AA 21 (51.2%) 20 (48.8) 1
  AG 24 (52.2%) 22 (47.8%) 0.963 0.962 0.415 2.235
  GG 5 (38.5%) 8 (61.5%) 0.420 1.68 0.470 6.007
 Dominant model
  AG + GG 29 (49.2%) 30 (50.8%) 0.839 1.086 0.489 2.214
 Recessive model
  AA + AG 45 (51.7%) 42 (48.3%) 0.376 0.583 0.177 1.925
 Allele
  A 66 (51.5%) 62 (48.4%) 1
  G 34 (47.2%) 38 (52.7%) 0.556 1.190 0.667 2.121
NBN rs1805794 C > G
 Genotype
  CC 28 (53.8%) 24 (46.2%) 1
  CG 22 (45.8%) 26 (54.2%) 0.42 1.378 0.628 3.029
  GG 0 (0.0%) 0 (0.0%)
 Dominant model
  CG + GG 22 (45.8%) 26 (54.2%) 0.423 1.378 0.628 3.029
 Recessive model
  CC + CG 50 (50.0%) 50 (50.0%)
 Allele
  C 78 (51.3%) 74 (48.6) 1
  G 22 (45.8%) 26 (54.1%) 0.508 1.246 0.650 2.388
NBN SNVs interaction
  B P-Value OR 95% CI for OR
Lower Upper
rs709816 by rs1805794 1.119 0.336 3.062 0.313 29.948
  1. Hardy–Weinberg Equilibrium (HWE) results for XRCC1 and NBN genes polymorphisms: rs1799782 (XRCC1 G > A), Control Group (χ2 = 0.13, P = 0.7), Case Group (χ2 = 0.04, P = 0.8); rs1805794 (NBN C > G): Control Group (χ2 = 3.97, P = 0.04), Case Group (χ2 = 6.17, P = 0.01); rs709816 (NBN A > G): Control Group (χ2 = 0.24, P = 0.62), Case Group (χ2 = 0.21, P = 0.63)