Table 1 Descriptive statistics of demographic and genetic data of all patients with diagnosed childhood glaucoma
From: Childhood glaucoma registry in Germany: initial database, clinical care and research (pilot study)
Number of patients, PCG/SCG | 28; 11/17 |
Age at presentation | |
Mean ± SD (range), months | 33.8 ± 36.5 (1–125) |
Mean ± SD (range), years | 2.8 ± 3 (0.07–10.41) |
Age at time of suspected glaucoma diagnosis, months | |
Mean ± SD (range) | 12.3 ± 24.9 (0–119.3) |
Sex, n (%) | |
Female/Male | 18 (64%)/10 (36%) |
Country of origin, mother/father, n (%) | |
German | 14 (50%)/14 (50%) |
East European countries | 5 (18%)/6 (21%) |
Asia | 7 (25%)/7 (25%) |
Africa | 2 (7%)/1 (4%) |
Country of birth, n (%) | |
German | 21 (75%) |
East European countries | 4 (14%) |
Asia | 3 (11%) |
Laterality, n (%) | |
Unilateral/Bilateral | 9 (32%)/19 (68%) |
Unilateral/Bilateral, PCG | 2 (18%)/9 (82%) |
Unilateral/Bilateral, SCG | 7 (41%)/10 (59%) |
Mean number of performed eye surgeries | 2 ± 3.7 |
Mean number of eye surgeries, performed at glaucoma department Mainz | 2 ± 3.2 |
Positive family history, n (%) | 6 (21%) |
Consanguinity, n (%) | 4 (14%) |
Risk factors during pregnancy, n (%) | |
Smoking | 2 (7%) |
Alcohol drinking | 3 (11%) |
Genetic examination | 24 (86%) |
Revealed genes’ mutations with their type and location, n (%) | 12 (50%) out of 24 |
CYP1B1 (2 compound heterozygous; 3 homozygous; 2p22.2) | 5 (21%) |
SOX11 (heterozygous; 2p25.2) | 1 (4%) |
TEK (heterozygous; 9p21.2) | 1 (4%) |
CRYBB3 (heterozygous; 22q11.23) | 1 (4%) |
FYCO1 (homozygous; 3p21.31) | 1 (4%) |
FOXC1 (heterozygous; 6p25.3) | 1 (4%) |
GJA8 (heterozygous; 1q21.2) | 1 (4%) |
LTBP2 (compound heterozygous; 14q24.3) | 1 (4%) |