Primary hypothyroidism and chronotypes in adult women

BMC Research Notes

Table 2 Chronotypes and sleep patterns of female patients with hypothyroidism (N = 81)

Feature	Patients with chronotype, %				Patients with chronotype, %
Feature	Early	Intermediate	Late	P value	Early	Intermediate/late	P value
Age, y				0.82			0.23
22–59	30.8	18.5	3.7		28.9	41.7
60–65	24.7	19.7	2.5		71.1	58.3
BMI				0.12			0.052
18.5–30 (Ideal and overweight)	39.5	18.5	3.7		71.1	50
> 30 (Obese)	16	19.7	2.5		28.9	50
Thyrotropin, mIU/L				0.25			0.06
< 4.20	44.4	35.8	6.2		80	94.4
≥ 4.20	11.1	2.5	0		20	5.6
Diabetes				0.64			0.81
Yes	13.6	9.9	0		24.4	22.2
No	41.9	28.4	6.2		75.6	77.8
Hemoglobin A_1c, %				0.07			0.09
≤ 7	10.5	26.3	0		18	57.1
> 7	47.3	15.8	0		81.8	8.3
Levothyroxine dose, mcg				0.77			0.09
< 100	28.4	17.3	3.7		73.3	55.5
≥ 100	27.2	20.9	2.5		26.7	44.4
Sleep latency, min				0.02			0.01
< 10	19.8	3.7	1.2		35.5	11.1
≥ 10	35.8	34.6	4.9		64.4	88.9
Total time in bed, h				0.45			0.18
< 8	23.5	11.1	1.2		42.2	27.8
≥ 8	32	27.2	4.9		57.8	69.4
Average weekly sleep duration, h				0.67			0.88
< 7	22.2	17.3	1.2		40	41.7
≥ 7	33.3	20.9	4.9		60	58.3
Weekly sleep loss, h				0.14			0.47
< 1	44.4	34.6	3.7		80	86.1
≥ 1	11.1	3.7	2.5		20	13.9
Average weekly light exposure, min				0.007			0.009
< 40	20.9	23.5	6.2		45.5	66.7
≥ 40	34.6	14.8	0		62.2	33.3
Cigarette smoking				0.78			0.78
Yes	3.7	3.7	0		6.7	8.3
No	51.9	34.6	6.2		93.3	91.7
Alcohol intake				0.004			0.001
Yes	2.5	11.1	2.5		4.4	30.6
No	53	27.2	3.7		95.6	69.4
Coffee intake				0.49			0.22
No	9.9	3.7	0		17.8	8.3
Yes	45.6	34.6	6.2		82.2	91.7
Sleep medication				0.47			0.26
Yes	12.3	13.6	1.2		22.2	33.3
No	43.2	24.7	4.9		77.8	66.7
Sleep duration, h				0.63			0.96
< 7	23.5	17.3	1.2		42.2	41.7
≥ 7	32	20.9	4.9		57.8	58.3

BMI, body mass index (calculated as weight in kilograms divided by height in meters squared)

ISSN: 1756-0500