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Table 2 Chronotypes and sleep patterns of female patients with hypothyroidism (N = 81)

From: Primary hypothyroidism and chronotypes in adult women

Feature Patients with chronotype, % Patients with chronotype, %
Early Intermediate Late P value Early Intermediate/late P value
Age, y     0.82    0.23
 22–59 30.8 18.5 3.7   28.9 41.7  
 60–65 24.7 19.7 2.5   71.1 58.3  
BMI     0.12    0.052
 18.5–30 (Ideal and overweight) 39.5 18.5 3.7   71.1 50  
  > 30 (Obese) 16 19.7 2.5   28.9 50  
Thyrotropin, mIU/L     0.25    0.06
  < 4.20 44.4 35.8 6.2   80 94.4  
  ≥ 4.20 11.1 2.5 0   20 5.6  
Diabetes     0.64    0.81
 Yes 13.6 9.9 0   24.4 22.2  
 No 41.9 28.4 6.2   75.6 77.8  
Hemoglobin A1c, %     0.07    0.09
  ≤ 7 10.5 26.3 0   18 57.1  
  > 7 47.3 15.8 0   81.8 8.3  
Levothyroxine dose, mcg     0.77    0.09
  < 100 28.4 17.3 3.7   73.3 55.5  
  ≥ 100 27.2 20.9 2.5   26.7 44.4  
Sleep latency, min     0.02    0.01
  < 10 19.8 3.7 1.2   35.5 11.1  
  ≥ 10 35.8 34.6 4.9   64.4 88.9  
Total time in bed, h     0.45    0.18
  < 8 23.5 11.1 1.2   42.2 27.8  
  ≥ 8 32 27.2 4.9   57.8 69.4  
Average weekly sleep duration, h     0.67    0.88
  < 7 22.2 17.3 1.2   40 41.7  
  ≥ 7 33.3 20.9 4.9   60 58.3  
Weekly sleep loss, h     0.14    0.47
  < 1 44.4 34.6 3.7   80 86.1  
  ≥ 1 11.1 3.7 2.5   20 13.9  
Average weekly light exposure, min     0.007    0.009
  < 40 20.9 23.5 6.2   45.5 66.7  
  ≥ 40 34.6 14.8 0   62.2 33.3  
Cigarette smoking     0.78    0.78
 Yes 3.7 3.7 0   6.7 8.3  
 No 51.9 34.6 6.2   93.3 91.7  
Alcohol intake     0.004    0.001
 Yes 2.5 11.1 2.5   4.4 30.6  
 No 53 27.2 3.7   95.6 69.4  
Coffee intake     0.49    0.22
 No 9.9 3.7 0   17.8 8.3  
 Yes 45.6 34.6 6.2   82.2 91.7  
Sleep medication     0.47    0.26
 Yes 12.3 13.6 1.2   22.2 33.3  
 No 43.2 24.7 4.9   77.8 66.7  
Sleep duration, h     0.63    0.96
  < 7 23.5 17.3 1.2   42.2 41.7  
  ≥ 7 32 20.9 4.9   57.8 58.3  
  1. BMI, body mass index (calculated as weight in kilograms divided by height in meters squared)