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Table 1 Preconception and trimester-wise Levothyroxine dosage administered in hypothyroid women

From: Levothyroxine dosages during pregnancy among hypothyroid women. An experience from a tertiary care center of Karachi, Pakistan, based on data from Maternal Hypothyroidism on Pregnancy Outcomes Study (MHPO-5)

Levothyroxine dosage (µg per day)

n = 280

Median (IQR)

P value*

Preconception dose

85.7 (55.3)

1st trimester dose

100.0 (69.6)

0.001

1st trimester dose

100.0 (69.6)

2nd trimester dose

100.0 (75.0)

 < 0.01

2nd trimester dose

100.0 (75.0)

3rd trimester dose

100.0 (96.4)

 < 0.01

  1. *P-Value calculated by Wilcoxon Signed Rank test