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Table 2 Comparison of serum cytokines among patient groups according to disease activity based on DAS28-ESR

From: Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

Serum cytokines

Low disease activity (n = 20)

Moderate disease activity (n = 21)

High disease activity (n = 39)

p value

IGF-1 (pg/ml)

166.200

(116.305, 307.555)

153.070

(100.038, 327.442)

229.920

(142.760, 423.772)

0.314

IGFBP-3 (pg/ml)

5359.140

(5001.525, 5901.715)

5818.650

(5105.312, 6321.658)

5732.090

(5277.685,

6779.132)

0.175

TNF-α (pg/ml)

6.545

7.661

9.680

0.650

 

(3.412, 13.093)

(4.109, 12.989)

(4.736, 13.789)

 

IL-1 (pg/ml)

2.189

2.262

2.557

0.270

 

(1.630, 2.939)

(2.066, 3.120)

(2.139, 3.092)

 

IL-6 (pg/ml)

1.819

(0.809, 2.588)

4.569

(2.871, 11.973)

13.399

(3.720, 36.984)

 < 0.001

  1. Numeral data are presented as mean ± one standard deviation, or number of patients with percentages in parentheses, as appropriate
  2. DAS28-ESR disease activity score in 28 joints with estimated sedimentation rate, IGF insulin-like growth factor, IGFBP insulin-like factor binding protein, IL interleukin, TNF-α tumor necrosis factor alpha