Chromosome | Tier 1 Hotspot Location | Mutation name | Hotspot Mutation | Bases at hotspot | C of CpG Normal (PBMC) | G of CpG Normal (PBMC) | C of CpG Immprtalized (PAM3005) | G of CpG Immprtalized (PAM3005) | C of CpG Cancer (HCT116) | G of CpG Cancer (HCT116) |
---|---|---|---|---|---|---|---|---|---|---|
chr11 | 108247071 | ATM R337C, c.1009C>T | C>T | CpG | 2.1% | 56.8% | 0.7% | 8.1% | ||
chr19 | 11021837 | SMARCA4 T910M, c.2729C>T | C>T | CpG | 2.0% | 6.1% | 1.1% | 2.2% | 10.7% | |
chr2 | 208248388 | IDH1 R132H, c.395G>A | C>T | CpG | 1.4% | 2.0% | 9.1% | 2.8% | 0.5% | |
chr1 | 162776212 | DDR2 R709, c.2125C>T | C>T | CpG | 7.1% | 0.3% | 8.9% | 9.6% | 7.4% | 20.5% |
chr17 | 39711955 | ERBB2 S310F, c.929C>T | C>T | CpG | 3.8% | 12.5% | 16.6% | |||
chr2 | 211623993 | ERBB4 R711C, c.2131C>T | G>A | CpG | 1.3% | 2.1% | 8.5% | 25.3% | 9.9% | 7.8% |
chr12 | 25245350 | KRAS G12C, c.34G>T | C>A | CC | 22.58% | 32.14% |
Chromosome | Tier 2 Hotspot Location | Mutation name | Hotspot Mutation | Bases at hotspot | C of CpG Normal (PBMC) | G of CpG Normal (PBMC) | C of CpG Immprtalized (PAM3005) | G of CpG Immprtalized (PAM3005) | C of CpG Cancer (HCT116) | G of CpG Cancer (HCT116) |
---|---|---|---|---|---|---|---|---|---|---|
chr17 | 7673802 | TP53 R273H, c.818G>A | C>T | CpG | 1.2% | 4.1% | 2.5% | 4.8% | 5.0% | 3.3% |
chr17 | 7674220 | TP53 R248Q, c.743G>A | C>T | CpG | 5.8% | 0.6% | 8.7% | 0.4% | 5.5% | 2.4% |
chr7 | 55181378 | EGFR T790M, c.2369C>T | C>T | CpG | 7.4% | 4.8% | 6.4% | 6.0% | 0.7% | |
chr17 | 7675088 | TP53 R175H, c.524G>A | C>T | CpG | 2.3% | 4.8% | 0.8% | 6.3% | 3.4% | 6.6% |
chr5 | 112839941 | APC R1450, c.4348C>T | G>A | CpG | 6.3% | 6.7% | 18.6% | |||
chr15 | 66436824 | MAP2K1 P124S, c.370C>T | C>T | CC | 7.2% | 5.7% | 3.8% | |||
chr14 | 104780214 | AKT1 E17K, c.49G>A | C>T | CC | 2.8% | 1.9% | 4.7% | |||
chr3 | 41224646 | CTNNB1 S45F, c.134C>T | C>T | TCT | 2.1% | 1.5% | 1.0% | |||
chr3 | 179218303 | PIK3CA E545K, c.1633G>A | G>A | TGA | 2.6% | 4.2% | 5.4% | |||
chrX | 71119404 | MED12 G44D, c.131G>A | G>A | GG | 5.1% | 5.4% | 5.9% |