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Table 1 Baseline Characteristics (number (percent); median [interquartile range])

From: Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations

Variable

Placebo (n = 9)

Sildenafil (n = 11)

P-value*

Maternal age at estimated date of delivery (years)

30.0 [29.0, 31.0]

33.5 [31.5, 37.3]

0.109

Nulliparity

5 (55.6%)

6 (54.5%)

0.964

Height (cm)

160.0 [160.0, 165.0]

159.0 [155.5, 165.8]

0.471

Weight (kg)

75.0 [68.7, 77.7]

69.4 [59.0, 83.7]

0.743

Body-mass index

27.1 [24.7, 29.3]

27.6 [22.4, 34.3]

0.543

Ethnicity

0.514

Caucasian

7 (77.8%)

6 (54.5%)

 

Afro-Canadian

1 (11.1%)

2 (18.2%)

 

South or East Asian

0 (0%)

2 (18.2%)

 

Other

1 (11.1%)

1 (9.1%)

 

Current smoker

0 (0%)

1 (9.1%)

1.000

Current antihypertensive treatment

0 (0%; chronic hypertension)

1 (9.1%)

1.000

Gestational diabetes

0 (0%; 1 [11.1%] woman subsequently diagnosed)

0 (0%)

0.918

Preterm prelabour rupture of membrane

0 (0%)

0 (0%)

NA

Systolic blood pressure with the highest prerandomization sBP (mmHg)

124.0 [108.0, 132.0]

124.0 [106.5, 136.0]

0.760

Diastolic blood pressure with the highest prerandomization dBP (mmHg)

72.0 [67.0, 75.0]

76.0 [70.5, 84.0]

0.127

Creatinine (μmol/L)

55.5 [53.75, 58.25]

56.0 [49.0, 57.8]

0.831

Uric acid (μmol/L)

265 [253, 278]

220 [210, 250]

0.571

Abnormal uterine artery Doppler

6 (66.7%)

6 (54.5%)

1.00

Fetal abdominal circumference < 1st percentile for GA

6 (66.7%)

8 (72.7%)

0.659

Estimated fetal weight (g)

301.0 [240.0, 488.0]

246.0 [234.5, 389.5]

0.403

Estimated fetal weight < 500 g

6 (66.7%)

9 (82.0%)

0.432

Umbilical artery Doppler end-diastolic flow

0.537

Intermittently absent

2 (22.2%)

1 (9.1%)

 

Persistently absent

3 (33.3%)

2 (18.2%)

 

Intermittently reversed

0 (0%)

1 (9.1%)

 

Reversed ductus venosus a-wave

0 (0%)

2 (18.2%)

0.600

Maternal PlGF (immediately prior to randomization)

12.0 [12.0, 12.0]

12.0 [12.0, 19.8]

0.447

GA at PlGF collection, eligibility & randomisation (weeks + days)

22+4 [21+5, 25+5]

21+5 [21+4, 23+5]

0.379

  1. * Fisher’s exact (dichotomous) or Mann Whitney U (continuous) test
  2. Elevated uterine artery pulsatility index for gestational age or persistent unilateral or bilateral notching