Variable | Placebo (n = 9) | Sildenafil (n = 11) | P-value* |
---|---|---|---|
Maternal age at estimated date of delivery (years) | 30.0 [29.0, 31.0] | 33.5 [31.5, 37.3] | 0.109 |
Nulliparity | 5 (55.6%) | 6 (54.5%) | 0.964 |
Height (cm) | 160.0 [160.0, 165.0] | 159.0 [155.5, 165.8] | 0.471 |
Weight (kg) | 75.0 [68.7, 77.7] | 69.4 [59.0, 83.7] | 0.743 |
Body-mass index | 27.1 [24.7, 29.3] | 27.6 [22.4, 34.3] | 0.543 |
Ethnicity | 0.514 | ||
Caucasian | 7 (77.8%) | 6 (54.5%) | |
Afro-Canadian | 1 (11.1%) | 2 (18.2%) | |
South or East Asian | 0 (0%) | 2 (18.2%) | |
Other | 1 (11.1%) | 1 (9.1%) | |
Current smoker | 0 (0%) | 1 (9.1%) | 1.000 |
Current antihypertensive treatment | 0 (0%; chronic hypertension) | 1 (9.1%) | 1.000 |
Gestational diabetes | 0 (0%; 1 [11.1%] woman subsequently diagnosed) | 0 (0%) | 0.918 |
Preterm prelabour rupture of membrane | 0 (0%) | 0 (0%) | NA |
Systolic blood pressure with the highest prerandomization sBP (mmHg) | 124.0 [108.0, 132.0] | 124.0 [106.5, 136.0] | 0.760 |
Diastolic blood pressure with the highest prerandomization dBP (mmHg) | 72.0 [67.0, 75.0] | 76.0 [70.5, 84.0] | 0.127 |
Creatinine (μmol/L) | 55.5 [53.75, 58.25] | 56.0 [49.0, 57.8] | 0.831 |
Uric acid (μmol/L) | 265 [253, 278] | 220 [210, 250] | 0.571 |
Abnormal uterine artery Doppler † | 6 (66.7%) | 6 (54.5%) | 1.00 |
Fetal abdominal circumference < 1st percentile for GA | 6 (66.7%) | 8 (72.7%) | 0.659 |
Estimated fetal weight (g) | 301.0 [240.0, 488.0] | 246.0 [234.5, 389.5] | 0.403 |
Estimated fetal weight < 500 g | 6 (66.7%) | 9 (82.0%) | 0.432 |
Umbilical artery Doppler end-diastolic flow | 0.537 | ||
Intermittently absent | 2 (22.2%) | 1 (9.1%) | |
Persistently absent | 3 (33.3%) | 2 (18.2%) | |
Intermittently reversed | 0 (0%) | 1 (9.1%) | |
Reversed ductus venosus a-wave | 0 (0%) | 2 (18.2%) | 0.600 |
Maternal PlGF (immediately prior to randomization) | 12.0 [12.0, 12.0] | 12.0 [12.0, 19.8] | 0.447 |
GA at PlGF collection, eligibility & randomisation (weeks + days) | 22+4 [21+5, 25+5] | 21+5 [21+4, 23+5] | 0.379 |