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Table 1 Study population with and without clinical failures or microbiological relapse

From: Correction of hyperglycemia after surgery for diabetic foot infection and its association with clinical outcomes

n = 1013 DFI episodes Clinical failurea p-value* Remission p-value* Microbiological relapsea
Male sex 203 (80%) 0.59 591 (78%) 0.43 59 (83%)
Median age 65 years 0.09 68 years 0.96 67 years
Median duration diabetes 18 years 0.03 20 years 0.86 18 years
Diabetic foot osteomyelitis 213 (84%) 0.06 669 (88%) 0.39 39 (83%)
Insulin therapy 192 (75%) 0.69 561 (74%) 0.51 33 (70%)
Peripheral arterial disease 559 (74%) 0.03 205 (80%) 0.59 37 (79%)
 Revascularization 164 (64%) 0.01 408 (54%) 0.64 25 (53%)
Median no. debridement 1 0.10 1 0.06 1
Median duration antibiotics 30 days 0.01 20 days 0.18 28 days
Median glycated hemoglob 7.5% 0.16 8.3% 0.32 8.3%
Median glycemia preoperat 7.8 mmol/l 0.27 8.4 mmol/l 0.10 8.6 mmol/l
Preoperat. high glycemiab 55 (30%) 0.16 70 (24%) 0.12 13 (16%)
Diabetes Nurse Counselling 54 (23%) 0.34 143 (17%) n. a n. a
 Median no. consult 1 0.38 1 n. a n. a
Normal glycemia by Day 3 90 (80%) 0.21 262 (85%) 0.12 27 (75%)
Median glycemia by day 3 7.4 mmol/l 0.27 7.1 mmol/l 0.51 7.7 mmol/l
Normal glycemia by day 7 86 (80%) 0.02 235 (88%) 0.03 25 (74%)
Median glycemia by day 7 7.2 mmol/l 0.30 6.7 mmol/l 0.83 6.9 mmol/l
Normalized glycemia 92 (85%) 0.19 275 (90%) 0.09 28 (80%)
  1. n. a.: not applied due to low number of events of interest in the corresponding analysis
  2. *P-values derived from a Pearson-χ2 or the Wilcoxon-ranksum-test comparing the variables between the neighbouring columns. Statistically significant results are displayed in bold
  3. aThe denominators are not constant and rely on available values (missing data not imputated)
  4. bNormal glycemia morning level set at 6.1 mmol/l (110 mg/dl)