Correction of hyperglycemia after surgery for diabetic foot infection and its association with clinical outcomes

BMC Research Notes

Table 1 Study population with and without clinical failures or microbiological relapse

n = 1013 DFI episodes	Clinical failure^a	p-value*	Remission	p-value*	Microbiological relapse^a
Male sex	203 (80%)	0.59	591 (78%)	0.43	59 (83%)
Median age	65 years	0.09	68 years	0.96	67 years
Median duration diabetes	18 years	0.03	20 years	0.86	18 years
Diabetic foot osteomyelitis	213 (84%)	0.06	669 (88%)	0.39	39 (83%)
Insulin therapy	192 (75%)	0.69	561 (74%)	0.51	33 (70%)
Peripheral arterial disease	559 (74%)	0.03	205 (80%)	0.59	37 (79%)
Revascularization	164 (64%)	0.01	408 (54%)	0.64	25 (53%)
Median no. debridement	1	0.10	1	0.06	1
Median duration antibiotics	30 days	0.01	20 days	0.18	28 days
Median glycated hemoglob	7.5%	0.16	8.3%	0.32	8.3%
Median glycemia preoperat	7.8 mmol/l	0.27	8.4 mmol/l	0.10	8.6 mmol/l
Preoperat. high glycemia^b	55 (30%)	0.16	70 (24%)	0.12	13 (16%)
Diabetes Nurse Counselling	54 (23%)	0.34	143 (17%)	n. a	n. a
Median no. consult	1	0.38	1	n. a	n. a
Normal glycemia by Day 3	90 (80%)	0.21	262 (85%)	0.12	27 (75%)
Median glycemia by day 3	7.4 mmol/l	0.27	7.1 mmol/l	0.51	7.7 mmol/l
Normal glycemia by day 7	86 (80%)	0.02	235 (88%)	0.03	25 (74%)
Median glycemia by day 7	7.2 mmol/l	0.30	6.7 mmol/l	0.83	6.9 mmol/l
Normalized glycemia	92 (85%)	0.19	275 (90%)	0.09	28 (80%)

n. a.: not applied due to low number of events of interest in the corresponding analysis
*P-values derived from a Pearson-χ² or the Wilcoxon-ranksum-test comparing the variables between the neighbouring columns. Statistically significant results are displayed in bold
^aThe denominators are not constant and rely on available values (missing data not imputated)
^bNormal glycemia morning level set at 6.1 mmol/l (110 mg/dl)

ISSN: 1756-0500