Table 1 Pro-inflammatory and vascular injury biomarkers
From: Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure
Analyte | Function |
|---|---|
IL-1β | Cytokine: potent mediator of the inflammatory response; innate Th2 inflammatory response |
IL-4 | Cytokine: innate Th2 inflammatory response |
IL-5 | Cytokine: essential for eosinophil differentiation and survival; innate Th2 inflammatory response |
IL-6 | Cytokine: pro-inflammatory roles; chronic inflammation |
IL-10 | Cytokine: induced by inflammation, role in limiting immune response |
IL-13 | Cytokine: innate Th2 inflammatory response |
IFN-γ | Cytokine: important immunoregulatory functions; activator of macrophages |
KC/GRO (CXCL1) | Chemokine: role in inflammation and as a chemoattractant for neutrophils |
TNFα | Cytokine: innate Th2 inflammatory response |
Adiponectin | Regulates glucose levels & fatty acid breakdown; positive association with cardiovascular mortality |
MCP1 (CCL2) | Chemotactic for monocytes and basophils; associated with cardiovascular diseases and cognitive decline |
sE-Selectin | Role in immunoadhesion; systemic endothelial dysfunction |
sICAM-1 | Role in immunoadhesion; systemic endothelial dysfunction |
TIMP1 | Regulator of extracellular matrix synthesis and degradation; biomarker of fibrosis |