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Table 2 Result of HBsAg, total anti-HBc, HBeAg, HBV DNA detection in engineered Dried Blood Spots (DBS) and corresponding plasma samples

From: Dried blood spot is the feasible matrix for detection of some but not all hepatitis B virus markers of infection

 

Plasma

Engineered DBS

Sensitivity (%)

Specificity (%)

Percent Agreement (%)

Positive

Negative

Positive

Negative

HBsAg

25

29

24

29

96.0

100

98.1

anti-HBc

9

45

9

45

100

100

100

HBeAg

7

13

20

0

100

0

35.0

HBV DNA

25

29

22

29

88.0

100

94.4

  1. anti-HBc: hepatitis B core antibody, DBS: dried blood spot, HBeAg: hepatitis B e antigen, HBsAg: hepatitis B surface antigens, HBV: hepatitis B virus