Table 1 Partial OTUB1 deficiency altered T cell but not DC frequencies in syngeneic pregnancies

total CD11c ⁺

OTUB1^+/+ x OTUB1^+/+

0.13 ± 1.18

2.49 ± 2.86

0.60 ± 0.61

3.12 ± 2.29

1.19 ± 0.93

OTUB1^+/− x OTUB1^+/−

0.39 ± 0.20

4.19 ± 0.89

0.82 ± 0.31

2.19 ± 1.06

0.85 ± 0.73

mature CD11c ⁺ CD80 ⁺

OTUB1^+/+ x OTUB1^+/+

0.01 ± 0.09

0.32 ± 0.60

0.07 ± 0.04

0.63 ± 0.79

0.25 ± 0.14

OTUB1^+/− x OTUB1^+/−

0.04 ± 0.05

1.03 ± 0.41

0.06 ± 0.03

0.85 ± 0.37

0.15 ± 0.09

mature CD11c ⁺ MHCII ⁺

OTUB1^+/+ x OTUB1^+/+

0.05 ± 0.31

1.24 ± 1.13

0.22 ± 0.26

0.28 ± 0.31

0.54 ± 0.47

OTUB1^+/− x OTUB1^+/−

0.11 ± 0.08

1.22 ± 0.16

0.36 ± 0.11

0.18 ± 0.21

0.28 ± 0.51

total CD8 ⁺

OTUB1^+/+ x OTUB1^+/+

85.88 ± 11.83

12.63 ± 3.87

22.65 ± 4.30

18.18 ± 7.14

1.08 ± 0.37

OTUB1^+/− x OTUB1^+/−

92.34 ± 2.73

16.63 ± 2.66

25.19 ± 4.10

24.80 ± 2.98

0.37 ± 0.51

total CD4 ⁺

OTUB1^+/+ x OTUB1^+/+

88.30 ± 9.53

12.38 ± 3.17

25.31 ± 4.89

20.48 ± 9.29

0.77 ± 1.26

OTUB1^+/− x OTUB1^+/−

95.74 ± 1.74

14.10 ± 6.52

29.34 ± 4.94

29.88 ± 8.43*

4.93 ± 1.98*

CD4 ⁺ Foxp3 ⁺ Treg

OTUB1^+/+ x OTUB1^+/+

1.34 ± 0.94

1.77 ± 0.76

3.64 ± 1.11

1.55 ± 1.01

0.06 ± 0.05

OTUB1^+/− x OTUB1^+/−

0.52 ± 0.27*

1.86 ± 0.40

3.69 ± 0.85

2.27 ± 0.55

0.13 ± 0.12*