Table 2 Partial OTUB1 deficiency altered splenic CD4⁺ T cell but not DC frequencies in allogeneic pregnancies

total CD11c ⁺

OTUB1^+/+ x BALB/c

0.81 ± 0.57

2.18 ± 0.55

1.36 ± 0.47

2.23 ± 0.48

2.82 ± 1.03

OTUB1^+/− x BALB/c

0.83 ± 0.51

2.42 ± 1.07

1.90 ± 0.64

2.61 ± 1.81

2.27 ± 1.34

mature CD11c ⁺ CD80 ⁺

OTUB1^+/+ x BALB/c

0.01 ± 0.03

0.33 ± 0.21

0.07 ± 0.02

0.47 ± 0.85

0.34 ± 0.12

OTUB1^+/− x BALB/c

0.02 ± 0.04

0.27 ± 0.24

0.03 ± 0.02

0.41 ± 0.46

0.24 ± 0.24

mature CD11c ⁺ MHCII ⁺

OTUB1^+/+ x BALB/c

0.12 ± 0.07

0.83 ± 0.23

0.56 ± 0.11

0.25 ± 0.12

1.43 ± 0.59

OTUB1^+/− x BALB/c

0.12 ± 0.10

0.95 ± 0.56

0.36 ± 0.14

0.29 ± 0.19

1.27 ± 0.33

total CD8 ⁺

OTUB1^+/+ x BALB/c

92.90 ± 3.89

9.05 ± 3.90

21.45 ± 7.85

21.05 ± 3.49

1.95 ± 1.97

OTUB1^+/− x BALB/c

90.40 ± 5.45

12.15 ± 2.34

25.30 ± 4.53

22.95 ± 3.31

0.81 ± 1.99

total CD4 ⁺

OTUB1^+/+ x BALB/c

97.17 ± 2.17

11.42 ± 1.78

21.24 ± 5.10

22.68 ± 7.77

5.53 ± 1.70

OTUB1^+/− x BALB/c

95.91 ± 4.84

14.44 ± 1.38*

25.68 ± 3.96

25.93 ± 8.77

3.44 ± 2.23

CD4 ⁺ Foxp3 ⁺ Treg

OTUB1^+/+ x BALB/c

0.87 ± 0.63

1.78 ± 0.63

3.38 ± 0.56

1.42 ± 0.65

0.14 ± 0.12

OTUB1^+/− x BALB/c

0.81 ± 0.65

1.63 ± 0.68

2.87 ± 0.55

1.71 ± 0.91

0.26 ± 0.21