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Fig. 1 | BMC Research Notes

Fig. 1

From: The effect of type-2 diabetes conditions on neutrophil rolling adhesion

Fig. 1

Effects of hyperglycemia on neutrophil rolling adhesion. a Neutrophil rolling velocities increase as a function of shear stress under different glucose concentrations (chronic exposure, dark to light red represent decreasing glucose concentrations). Error bars represent the first and third quartiles. b Cell projection area is not changed as a function of media glucose concentration. (n = 50, 655, 269, 16, 539, 105, 29, 335, 163, 33, 315, 134 cells) c, d Acute changes in glucose concentration have no detectable effect on neutrophil rolling velocity (c) or size (d). All data correspond to rolling at 0.29 Pa. (n = 432, 1213, 535, 326, 1787, 513 cells) e, f Neutrophils cultured under the same glucose concentration but differing mannitol concentrations in media exhibit similar rolling velocity and size. (dark and light green represent high and low mannitol concentration. n = 1332, 474, 639, 751, 519, 391, 1100, 384, 231, 216 cells) Statistical significance was tested by 1-way ANOVA, (ns) no significance, (*) p-value < 0.01, (**) p-value < 0.001

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