From: Loss of tumor suppressor menin expression in high grade cholangiocarcinomas
Menin staining (IHC score) | Total | P-valuea | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | |||||||
A | ||||||||||
Age (years) | n | % | n | % | n | % | n | % | n | |
≤ 50 | 18 | 56.25 | 3 | 9.38 | 7 | 21.88 | 4 | 12.5 | 32 | 0.1504 |
> 50 | 40 | 61.54 | 15 | 23.1 | 6 | 9.23 | 4 | 6.15 | 65 | |
B | ||||||||||
Sex | ||||||||||
F | 25 | 59.52 | 7 | 16.7 | 8 | 19.05 | 2 | 4.76 | 42 | 0.4114 |
M | 33 | 60 | 11 | 20 | 5 | 9.09 | 6 | 10.91 | 55 | |
C | ||||||||||
AJCC Stage | ||||||||||
II | 22 | 52.38 | 6 | 14.3 | 8 | 19.05 | 6 | 14.29 | 42 | 0.3206 |
III | 14 | 63.64 | 6 | 27.3 | 1 | 4.55 | 1 | 4.55 | 22 | |
IVA | 22 | 66.67 | 6 | 18.2 | 4 | 12.12 | 1 | 3.03 | 33 | |
D | ||||||||||
Grade | n | % | n | % | n | % | n | % | n | |
I | 1 | 10 | 2 | 20 | 3 | 30 | 4 | 40 | 10 | 0.0005 |
II | 25 | 56.8 | 8 | 18 | 8 | 18.2 | 3 | 6.8 | 44 | |
III | 32 | 74.4 | 8 | 19 | 2 | 4.7 | 1 | 2.3 | 43 | |
E | ||||||||||
Fibrosis | ||||||||||
N | 56 | 81.2 | 7 | 10 | 2 | 2.9 | 4 | 5.8 | 69 | < .0001 |
Y | 2 | 7.1 | 11 | 39 | 11 | 39.3 | 4 | 14.3 | 28 | |
F | ||||||||||
Grade | Patients without fibrosis | |||||||||
I | 1 | 12.5 | 2 | 25 | 2 | 25 | 3 | 37.5 | 8 | < .0001 |
II | 24 | 85.7 | 3 | 10.7 | 0 | 0 | 1 | 3.6 | 28 | |
III | 31 | 93.9 | 2 | 6.1 | 0 | 0 | 0 | 0 | 33 | |
G | ||||||||||
Grade | Patients with fibrosis | |||||||||
I | 0 | 0 | 0 | 0 | 1 | 50 | 1 | 50 | 2 | 0.3829 |
II | 1 | 6.3 | 5 | 31 | 8 | 50 | 2 | 12.5 | 16 | |
III | 1 | 10 | 6 | 60 | 2 | 20 | 1 | 10 | 10 |