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Table 2 Discontinuation rates of contraceptive method at 3 and 12- months according to side effects

From: Can a 3 months treatment with oral Desogestrel prior to insertion of the etonogestrel-releasing contraceptive implant improve continuation rate at 1 year? A randomized trial

Variable

ENG-Implant

 

DSG + ENG-Implant

 

3 M

12 M

3 M

15 M

n (%)

P value

n (%)

P value

n (%)

P value

n (%)

P value

Total

3

 

4

 

7

 

8

 

Weight gain

 

0.025

 

0.787

 

0.574

 

0.658

 No

0

 

1 (10.0)

 

6 (21.4)

 

4 (30.8)

 

 Yes

3 (33.3)

 

1 (14.3)

 

1 (12.5)

 

3 (23.1)

 

Headache

 

0.955

 

0.502

 

0.868

 

0.502

 Never or rarely

2 (13.3)

 

2 (13.3)

 

5 (29.8)

 

2 (13.3)

 

 Often to frequently

1 (12.5)

 

0

 

2 (18.2)

 

0

 

Acne

 

0.168

 

0.502

 

0.124

 

0.128

 Never or rarely

0

 

2 (13.3)

 

2 (9.1)

 

4 (18.2)

 

 Often to frequently

1 (14.3)

 

0

 

4 (33.3)

 

3 (60.0)

 

 All the time

1 (33.3)

 

_

 

1 (50.0)

 

1 (50.0)

 

Abdominal pain/bloating

 

0.484

 

0.502

 

0.273

 

0.299

 Never or rarely

1 (8.3)

 

2 (13.3)

 

5 (23.8)

 

5 (22.7)

 

 Often to frequently

2 (18.2)

 

0

 

1 (7.7)

 

3 (42.9)

 

Mastodynia

 

0.567

 

0.596

 

0.701

 

0.009

 Never or rarely

3 (14.3)

 

2 (12.5)

 

6 (20.7)

 

3 (14.3)

 

 Often to frequently

0

 

0

 

1 (14.3)

 

5 (62.5)

 

Vaginal infection

 

0.263

 

0.799

 

0.766

 

0.603

 Never or rarely

2 (10.0)

 

2 (13.3)

 

6 (18.8)

 

6 (24.0)

 

 Often to frequently

1 (33.3)

 

0

 

1 (25.0)

 

1 (50.0)

 

Mood Swings

 

0.012

 

0.289

 

0.386

 

0.128

 Never or rarely

2 (20.0)

 

2 (15.7)

 

3 (14.3)

 

2 (12.5)

 

 Often to frequently

0

 

0

 

4 (30.8)

 

4 (44.4)

 

 All the time

1 (100.0)

 

_

 

0

 

2 (50.0

 

Reduced sex drive

 

0.029

 

0.836

 

0.012

 

0.657

 Never or rarely

1 (7.1)

 

1 (9.1)

 

3 (12.5)

 

5 (25.0)

 

 Often to frequently

1 (12.5)

 

1 (16.7)

 

2 (22.2)

 

3 (37.5)

 

 All the time

1 (100.0)

 

0

 

2 (100.0)

 

0

 

Irregular vaginal bleeding

 

0.019

 

0.461

 

0.862

 

0.010

 Never or rarely

0

 

1 (12.5)

 

2 (15.4)

 

2 (20.0)

 

 Often to frequently

0

 

0

 

3 (20.0)

 

1 (8.3)

 

 Constant

3 (42.9)

 

1 (25.0)

 

2 (25.0)

 

5 (71.4)

 
  1. ENG-Implant  Etonogestrel-releasing contraceptive implant; DSG + ENG-Implant  Daily oral 75 µg of desogestrel (DSG) for 3 months prior to the insertion of ENG-implant; n  number; 3 M assessment at 3 months; 12 M  assessment at 12 months.