Combination therapy: synergism among three plant extracts against selected pathogens

BMC Research Notes

Table 1 Representative MIC (mg/mL) and FICI of L. barteri, S. alata and R. communis extracts in combination

LBA + SAA	E. coli	S. aureus	P. aeruginosa	K. pneumoniae	C. albicans
MIC	1.17	3.12	1.56	2.34	3.12
FICI	0.56	0.50	0.50	0.56	0.50
Effect	A	S	S	A	S

LBA + SAE	E. coli	S. aureus	P. aeruginosa	K. pneumoniae	C. albicans
MIC	1.56	1.95	1.56	3.12	3.12
FICI	0.50	0.47	0.50	0.50	0.50
Effect	S	S	S	S	S

LBA + RCA	E. coli	S. aureus	P. aeruginosa	K. pneumoniae	C. albicans
MIC	1.56	1.95	1.17	3.12	3.12
FICI	0.50	0.78	0.56	0.50	0.50
Effect	S	A	A	S	S

LBA + RCE	E. coli	S. aureus	P. aeruginosa	K. pneumoniae	C. albicans
MIC	1.56	4.69	1.56	1.95	2.44
FICI	0.50	0.56	0.50	0.47	0.29
Effect	S	A	S	S	S

MIC Minimum inhibition concentration, FICI Fractional inhibition concentration index, S Synergy, A Additive; LBA Lannea barteri aqueous extract, LBE Lannea barteri ethanol extract, SAA Senna alata aqueous extract, SAE Senna alata ethanol extract, RCA Ricinus communis aqueous extract, RCE Ricinus communis ethanol extract

ISSN: 1756-0500