Table 2 Clinical profile, presentations and outcomes of patients who were admitted due to warfarin toxicity at the Jigme Dorji Wangchuck National Referral Hospital, Thimphu between 2018–2020
Variables | n | (%) |
|---|---|---|
Total | 22 | (100) |
Clinical profile | ||
Warfarin dose administered by self | 22 | (100.0) |
Recent hospital admission with bleeding | 3 | (13.6) |
Concomitant drug | ||
Antiarrhythmic* | 13 | (59.1) |
Antibiotics** | 10 | (45.5) |
Atorvastatin | 2 | (9.1) |
Low dose aspirin (< 100 mg) | 2 | (9.1) |
High dose aspirin (≥ 100 mg) | 0 | (0.0) |
Presumed cause of warfarin toxicity | ||
Dosing error by patient | 12 | (54.5) |
Drug interactions | 3 | (13.6) |
Drug interaction – unknown agent | 1 | (4.5) |
Cause not identified | 6 | (27.3) |
Clinical presentation and outcomes | ||
Clinical presentations | ||
Bleeding | 19 | (86.4) |
Skin necrosis | 3 | (13.6) |
Admission from | ||
Emergency Department | 19 | (86.4) |
Outpatient department | 2 | (9.1) |
Referral | 1 | (4.5) |
Treatments provided | ||
Stopped Warfarin | 19 | (86.4) |
Reduced dose of Warfarin | 10 | (45.5) |
Vitamin K | 15 | (68.2) |
Fresh frozen plasma transfusion | 20 | (90.9) |
Packed red blood cell transfusion | 15 | (68.2) |
Outcomes | ||
Discharged | 22 | (100) |