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  1. Content type: Technical Note

    Massive computational power is needed to analyze the genomic data produced by next-generation sequencing, but extensive computational experience and specific knowledge of algorithms should not be necessary to ...

    Authors: Justin T Page, Zachary S Liechty, Mark D Huynh and Joshua A Udall

    Citation: BMC Research Notes 2014 7:829

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  2. Content type: Technical Note

    Sequence alignments are used to find evidence of homology but sometimes contain regions that are difficult to align which can interfere with the quality of the subsequent analyses. Although it is possible to r...

    Authors: Marie Lisandra Zepeda Mendoza, Sanne Nygaard and Rute R da Fonseca

    Citation: BMC Research Notes 2014 7:806

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  3. Content type: Research article

    Leishmaniasis,a broad spectrum of diseases caused by several sister species of protozoa belonging to family trypanosomatidae and genus leishmania , generally affects poorer sections of the populace in third wo...

    Authors: Barnali Waugh, Ambarnil Ghosh, Dhananjay Bhattacharyya, Nanda Ghoshal and Rahul Banerjee

    Citation: BMC Research Notes 2014 7:802

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  4. Content type: Research article

    With diminishing costs of next generation sequencing (NGS), whole genome analysis becomes a standard tool for identifying genetic causes of inherited diseases. Commercial NGS service providers in general not o...

    Authors: Pankaj Kumar, Mashael Al-Shafai, Wadha Ahmed Al Muftah, Nader Chalhoub, Mahmoud F Elsaid, Alice Abdel Aleem and Karsten Suhre

    Citation: BMC Research Notes 2014 7:747

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  5. Content type: Technical Note

    Heterogeneity in the features, input-output behaviour and user interface for available bioinformatics tools and services is still a bottleneck for both expert and non-expert users. Advancement in providing com...

    Authors: Ahmet Yildiz, Erkan Dilaveroglu, Ilhami Visne, Bilal Günay, Emrah Sefer, Andreas Weinhausel, Frank Rattay, Carole A Goble, Ram Vinay Pandey and Albert Kriegner

    Citation: BMC Research Notes 2014 7:740

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  6. Content type: Technical Note

    Chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-Seq) provides a powerful tool for discovering protein-DNA interactions. Still, the computational analysis of the great amount of ChIP...

    Authors: Krzysztof Chojnowski, Krzysztof Goryca, Tymon Rubel and Michal Mikula

    Citation: BMC Research Notes 2014 7:676

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  7. Content type: Research article

    Proteins that share a high sequence homology while exhibiting drastically different 3D structures are investigated in this study. Recently, artificial proteins related to the sequences of the GA and IgG bindin...

    Authors: Masanari Matsuoka, Masatake Sugita and Takeshi Kikuchi

    Citation: BMC Research Notes 2014 7:654

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  8. Content type: Research article

    Hepatitis C virus (HCV) causes chronic hepatitis C in 2-3% of world population and remains one of the health threatening human viruses, worldwide. In the absence of an effective vaccine, therapeutic approach i...

    Authors: Amir Hossein KayvanJoo, Mansour Ebrahimi and Gholamreza Haqshenas

    Citation: BMC Research Notes 2014 7:565

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  9. Content type: Research article

    Epidemiological studies have shown that consumption of a high-fat diet (HFD) increases the risk of developing breast cancer (BC). Studies in rodents have shown HFD causes changes in the genetic programming of ...

    Authors: Raquel C Martinez-Chacin, Megan Keniry and Robert K Dearth

    Citation: BMC Research Notes 2014 7:543

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  10. Content type: Research article

    Members of the Orthomyxoviridae family, which contains an important fish pathogen called the infectious salmon anemia virus (ISAV), have a genome consisting of eight segments of single-stranded RNA that encode di...

    Authors: Álvaro Díaz, Katherine García, Andrea Navarrete, Gastón Higuera and Jaime Romero

    Citation: BMC Research Notes 2014 7:477

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  11. Content type: Research article

    SG2NA is a member of the striatin sub-family of WD-40 repeat proteins. Striatin family members have been associated with diverse physiological functions. SG2NA has also been shown to have roles in cell cycle p...

    Authors: Sangeeta Soni, Chetna Tyagi, Abhinav Grover and Shyamal K Goswami

    Citation: BMC Research Notes 2014 7:446

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  12. Content type: Research article

    The most important means of identifying diseases before symptoms appear is through the discovery of disease-associated biomarkers. Recently, microRNAs (miRNAs) have become highly useful biomarkers of infectiou...

    Authors: Teresia Buza, Mark Arick II, Hui Wang and Daniel G Peterson

    Citation: BMC Research Notes 2014 7:403

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  13. Content type: Data Note

    Clonorchiasis, which is primarily caused by liver fluke (Platyhelminthes), is a fatal infectious disease that is mainly associated with bile duct malignancy and the subsequent development of cholangiocarcinoma...

    Authors: Dae-Won Kim, Won Gi Yoo, Sanghyun Lee, Myoung-Ro Lee, Yu-Jung Kim, Shin-Hyeong Cho, Won-Ja Lee and Jung-Won Ju

    Citation: BMC Research Notes 2014 7:388

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  14. Content type: Data Note

    MITE, TRIM and SINEs are miniature form transposable elements (mTEs) that are ubiquitous and dispersed throughout entire plant genomes. Tens of thousands of members cause insertion polymorphism at both the int...

    Authors: Jayakodi Murukarthick, Perumal Sampath, Sang Choon Lee, Beom-Soon Choi, Natesan Senthil, Shengyi Liu and Tae-Jin Yang

    Citation: BMC Research Notes 2014 7:379

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  15. Content type: Technical Note

    The fast reduction of prices of DNA sequencing allowed rapid accumulation of genome data. However, the process of obtaining complete genome sequences is still very time consuming and labor demanding. In additi...

    Authors: Vitor C Piro, Helisson Faoro, Vinicius A Weiss, Maria BR Steffens, Fabio O Pedrosa, Emanuel M Souza and Roberto T Raittz

    Citation: BMC Research Notes 2014 7:371

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  16. Content type: Research article

    High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality of miRNA expression data based on microarray tech...

    Authors: Alain Sewer, Sylvain Gubian, Ulrike Kogel, Emilija Veljkovic, Wanjiang Han, Arnd Hengstermann, Manuel C Peitsch and Julia Hoeng

    Citation: BMC Research Notes 2014 7:302

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