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  1. Content type: Research article

    The aim of the present study is to assess efficacy and efficiency of Volumetric-modulated arc therapy (VMAT) technique in treatment of nasopharyngeal cancer in our institution and to report toxicity related to...

    Authors: Issam Lalya, El Amin Marnouche, Maghous Abdelhak, Noha Zaghba, Khalid Andaloussi, Mohamed Elmarjany, Laila Baddouh, Keltoum Dahmani, Khalid Hadadi, Hassan Sifat and Hamid Mansouri

    Citation: BMC Research Notes 2017 10:112

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  2. Content type: Short Report

    Antineoplastic activity has been previously shown for two isomeric flavones, 5,7-dihydroxy-3,6,8-trimethoxy flavone (flavone A) and 3,5-dihydroxy-6,7,8-trimethoxy flavone (flavone B), against colon cancer cell...

    Authors: Crystal L. Whitted, Victoria E. Palau, Ruben D. Torrenegra, Oscar E. Rodriguez and Sam Harirforoosh

    Citation: BMC Research Notes 2017 10:29

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  3. Content type: Case Report

    Male breast cancer is a rare event, accounting for approximately 1% of all breast carcinomas. Although men with breast cancer had poorer survival when compared with women, data on prognosis principally derive ...

    Authors: Z. Ballatore, M. Pistelli, N. Battelli, A. Pagliacci, M. De Lisa, R. Berardi and S. Cascinu

    Citation: BMC Research Notes 2016 9:497

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  4. Content type: Research article

    Both abiraterone acetate (AA) and enzalutamide are promising agents for patients with pre- and post-chemotherapy metastatic castration-resistant prostate cancer (mCRPC). Several retrospective analysis suggeste...

    Authors: Yoko Yamada, Nobuaki Matsubara, Ken-ichi Tabata, Takefumi Satoh, Naoto Kamiya, Hiroyoshi Suzuki, Takashi Kawahara, Hiroji Uemura, Akihiro Yano and Satoru Kawakami

    Citation: BMC Research Notes 2016 9:471

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  5. Content type: Research article

    Systemic chemotherapy with gemcitabine and cisplatin is standard of care for patients with metastatic urothelial bladder cancer. However, resistance formation is common after initial response. The protein Src ...

    Authors: Stefan Vallo, Martin Michaelis, Kilian M. Gust, Peter C. Black, Florian Rothweiler, Hans-Michael Kvasnicka, Roman A. Blaheta, Maximilian P. Brandt, Felix Wezel, Axel Haferkamp and Jindrich Cinatl Jr.

    Citation: BMC Research Notes 2016 9:454

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  6. Content type: Research article

    The Danish Neuro-Oncology Registry (DNOR) is a nationwide clinical cancer database that has prospectively registered data on patients with gliomas since January 2009. The purpose of this study was to describe ...

    Authors: Steinbjørn Hansen, Jan Nielsen, René J. Laursen, Birthe Krogh Rasmussen, Bente Mertz Nørgård, Kim Oren Gradel and Rikke Guldberg

    Citation: BMC Research Notes 2016 9:425

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  7. Content type: Case Report

    Cowden syndrome is an autosomal dominant disorder with a predisposition to multiple benign and malignant tumors. In our patient, in addition to breast and endometrial malignancies as well as facial trichilemmo...

    Authors: Maria Angela Gosein, Dylan Narinesingh, Cemonne Ann-Alicia Celeste Nixon, Sanjeeva Reddy Goli, Paramanand Maharaj and Alexander Sinanan

    Citation: BMC Research Notes 2016 9:388

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  8. Content type: Case Report

    Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. Treatment recommendations are currently based on case reports and small serie...

    Authors: Charlotte R. Lemech, Rachel Williams, Stephen R. Thompson, Brian McCaughan and Melvin Chin

    Citation: BMC Research Notes 2016 9:386

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  9. Content type: Case Report

    The gastrointestinal tract is a relatively common involvement site in lymphoma and, in such cases, intestinal perforation is a concern before and during chemotherapy. The prediction of intestinal perforation p...

    Authors: Osamu Imataki, Kohei Shiroshita, Shumpei Uchida, Jun-ichiro Kida, Shintaro Akamoto and Makiko Uemura

    Citation: BMC Research Notes 2016 9:308

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  10. Content type: Research article

    BRCA1 and BRCA2 genes explain a large part of hereditary breast cancer. Several studies have shown that BRCA1 and BRCA2 tumors exhibit some specific morphological and immunohistochemic...

    Authors: Hassan Jouhadi, Amal Tazzite, Houssine Azeddoug, Asmâa Naim, Sellama Nadifi and Abdellatif Benider

    Citation: BMC Research Notes 2016 9:248

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  11. Content type: Short Report

    African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we pros...

    Authors: Jay H. Fowke, Xijing Han, J. F. Alderete, Kelvin A. Moses, Lisa B. Signorello and William J. Blot

    Citation: BMC Research Notes 2016 9:224

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  12. Content type: Research article

    Ovarian cancer is the most lethal gynecologic malignancy and it represents third most common malignancy in Karachi (after breast and oral cancer). Due to lack of well established cancer registry in our country...

    Authors: Atif Ali Hashmi, Zubaida Fida Hussain, Aneel Roy Bhagwani, Muhammad Muzzammil Edhi, Naveen Faridi, Syed Danish Hussain and Mehmood Khan

    Citation: BMC Research Notes 2016 9:205

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  13. Content type: Research article

    Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecita...

    Authors: J. S. Graham, K. Boyd, F. Y. Coxon, L. R. Wall, M. M. Eatock, T. S. Maughan, M. Highley, E. Soulis, S. Harden, P. Bützberger-Zimmerli and T. R. J. Evans

    Citation: BMC Research Notes 2016 9:161

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  14. Content type: Research article

    Familial cancer includes some types of cancer aggregation without a well-defined inheritance pattern. Cancer genetics is an essential component of clinical practice in oncology. In Brazil, breast cancer is th...

    Authors: Maria Hilda Araújo Ribeiro, Marcos Antonio Custódio Neto da Silva, Walbert Edson Muniz Filho, Anna Cyntia Brandão Nascimento, Rodrigo Duart Martins Souza, Carlos Eduardo Everton Machado, Dulcelena Ferreira Silva, Geusa Felipa de Barros Bezerra, Graça Maria de Castro Viana and Maria do Desterro Soares Brandão Nascimento

    Citation: BMC Research Notes 2016 9:155

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  15. Content type: Research

    Based on promising preclinical data, ketogenic diets (KDs) have been proposed as supplementary measures for cancer patients undergoing standard-of-care therapy. However, data is still scarce on the tolerabilit...

    Authors: Rainer J. Klement and Reinhart A. Sweeney

    Citation: BMC Research Notes 2016 9:143

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  16. Content type: Research article

    Despite advances in targeted therapy for lung cancer, survival for patients remains poor and lung cancer remains the leading cause of cancer-related deaths worldwide. The type I insulin-like growth factor rece...

    Authors: S. Elizabeth Franks, Robert A. Jones, Ritesh Briah, Payton Murray and Roger A. Moorehead

    Citation: BMC Research Notes 2016 9:134

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  17. Content type: Case Report

    Maffucci syndrome is characterized by the sporadic occurrence of multiple enchondromas together with multiple hemangiomas. Patients with Maffucci syndrome are at increased risk of developing different kinds of...

    Authors: Olga Prokopchuk, Stephanie Andres, Karen Becker, Konstantin Holzapfel, Daniel Hartmann and Helmut Friess

    Citation: BMC Research Notes 2016 9:126

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  18. Content type: Research article

    The tumor cells were needed to rearrange the extracellular matrix (ECM) and reorganize their cytoskeleton to facilitate the cell motility during the tumor invasion. The proinflammatory cytokine interleukin-17A...

    Authors: Takuma Sakurai, Daigo Yoshiga, Wataru Ariyoshi, Toshinori Okinaga, Hiroyasu Kiyomiya, Junya Furuta, Izumi Yoshioka, Kazuhiro Tominaga and Tatsuji Nishihara

    Citation: BMC Research Notes 2016 9:68

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  19. Content type: Case Report

    Invasive papillary carcinoma is a rare type of invasive ductal carcinoma. Neoadjuvant endocrine therapy is now considered as an optional therapy for postmenopausal women with hormone receptor-positive breast c...

    Authors: Chiaki Saita, Risa Goto, Tomoyuki Aruga, Nami Idera, Yayoi Honda, Kazumi Horiguchi, Hiromi Miyamoto, Shinichiro Horiguchi, Toshinari Yamashita and Katsumasa Kuroi

    Citation: BMC Research Notes 2016 9:46

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  20. Content type: Data Note

    Prostate cancer is the most commonly diagnosed and prevalent malignancy reported to Australian cancer registries, with numerous studies from single institutions summarizing patient outcomes at individual hospi...

    Authors: Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, John Zalcberg, Jeremy Millar and Sue Evans

    Citation: BMC Research Notes 2016 9:37

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  21. Content type: Research article

    Pulmonary pleomorphic carcinoma (PPC) follows an aggressive clinical course and outcomes are disappointing. Due to its rarity, however, the clinicopathological and molecular characteristics of this disease rem...

    Authors: Yosuke Tamura, Yutaka Fujiwara, Noboru Yamamoto, Hiroshi Nokihara, Hidehito Horinouchi, Shintaro Kanda, Yasushi Goto, Emi Kubo, Shinsuke Kitahara, Kenjiro Tsuruoka, Koji Tsuta and Yuichiro Ohe

    Citation: BMC Research Notes 2015 8:800

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  22. Content type: Research article

    The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using ...

    Authors: Nicolas Berthet, Lionel Frangeul, Ken André Olaussen, Elisabeth Brambilla, Nicolas Dorvault, Philippe Girard, Pierre Validire, Elie Fadel, Christiane Bouchier, Antoine Gessain and Jean-Charles Soria

    Citation: BMC Research Notes 2015 8:782

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  23. Content type: Research article

    Head and neck cancer (HNC) is one of the most common cancers worldwide and its incidence is reported to be increasing in resource-limited countries. There is a paucity of published data regarding head and neck...

    Authors: Japhet M. Gilyoma, Peter F. Rambau, Nestory Masalu, Neema M. Kayange and Phillipo L. Chalya

    Citation: BMC Research Notes 2015 8:772

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  24. Content type: Research article

    Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signat...

    Authors: Tangeng Ma, Claire A. Schreiber, Gaylord J. Knutson, Abdelouahid El Khattouti, Marcelo J. Sakiyama, Mohamed Hassan, Mary Christine Charlesworth, Benjamin J. Madden, Xinchun Zhou, Stanimir Vuk-Pavlović and Christian R. Gomez

    Citation: BMC Research Notes 2015 8:687

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  25. Content type: Research article

    There is an urgent need to identify molecular signatures in small cell lung cancer (SCLC) that may select patients who are likely to respond to molecularly targeted therapies. In this study, we investigate the...

    Authors: Fatma Abdelraouf, Adam Sharp, Manisha Maurya, Debbie Mair, Andrew Wotherspoon, Alex Leary, David Gonzalez de Castro, Jaishree Bhosle, Ayatallah Nassef, Taghrid Gaafar, Sanjay Popat, Timothy A. Yap and Mary O’Brien

    Citation: BMC Research Notes 2015 8:688

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  26. Content type: Research article

    To elucidate the optimal number of prostate biopsy cores using a nomogram allocating 6–12 biopsy cores, the number generally used in daily practice, based on age and prostate volume (PV).

    Authors: Nobumichi Tanaka, Keiji Shimada, Yoshinori Nakagawa, Shuya Hirao, Shuji Watanabe, Makito Miyake, Satoshi Anai, Akihide Hirayama, Noboru Konishi and Kiyohide Fujimoto

    Citation: BMC Research Notes 2015 8:689

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  27. Content type: Research article

    The magnitude of participation bias due to non-participation should be considered for cancer patients invited to population-based surveys. We studied participation rates among persons with and without cancer i...

    Authors: Sophie D. Fosså, Alv A. Dahl, Arnulf Langhammer and Harald Weedon-Fekjær

    Citation: BMC Research Notes 2015 8:649

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  28. Content type: Research article

    Modified response evaluation criteria in solid tumors (mRECIST) and RECIST are used to assess the effect of treatment with targeted agents for hepatocellular carcinoma (HCC). The aim of this study was to deter...

    Authors: Juichi Takada, Hisashi Hidaka, Takahide Nakazawa, Masaaki Kondo, Kazushi Numata, Katsuaki Tanaka, Kotaro Matsunaga, Chiaki Okuse, Satoshi Kobayashi, Manabu Morimoto, Shinichi Ohkawa and Wasaburo Koizumi

    Citation: BMC Research Notes 2015 8:609

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  29. Content type: Short Report

    Occupational ultraviolet radiation (UVR) exposure is a risk factor for skin cancer, and Hispanic individuals are over-represented in a number of outdoor occupations (e.g., farming, landscaping). This study exa...

    Authors: Ashley K. Day, Jerod L. Stapleton, Ana M. Natale-Pereira, James S. Goydos and Elliot J. Coups

    Citation: BMC Research Notes 2015 8:578

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  30. Content type: Research article

    Recent studies have pointed towards a role of tumour-infiltrating neutrophils in cancer biology. Investigations on oral squamous cell carcinoma have indicated a possible association with clinical characteristi...

    Authors: Patrícia Carlos Caldeira, Alexandre de Andrade Sousa and Maria Cássia Ferreira de Aguiar

    Citation: BMC Research Notes 2015 8:569

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  31. Content type: Case Report

    Regorafenib is a multi-targeted tyrosine kinase inhibitor approved for use in refractory colorectal cancer. We report the first case of seizures secondary to acute liver failure, shortly after initiation of r...

    Authors: Soundouss Raissouni, Zarqa Quraishi, Mohammed Al-ghamdi, Jose Monzon, Patricia Tang and Michael M. Vickers

    Citation: BMC Research Notes 2015 8:538

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  32. Content type: Research article

    Breast cancer is a major cause of death for women in Japan. The objectives of this study were to estimate and project the economic burden associated with breast cancer in Japan and identify the key factors tha...

    Authors: Kunichika Matsumoto, Kayoko Haga, Takefumi Kitazawa, Kanako Seto, Shigeru Fujita and Tomonori Hasegawa

    Citation: BMC Research Notes 2015 8:539

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  33. Content type: Research article

    Recently women’s lung cancer mortality rates have dramatically increased in developed countries, contrasting with a levelling off or decrease among men. Descriptive epidemiological data on primary lung cancer ...

    Authors: Fatima Az-zahra Zakkouri, Ouaouch Saloua, Abahssain Halima, Razine Rachid, Mrabti Hind and Errihani Hassan

    Citation: BMC Research Notes 2015 8:530

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  34. Content type: Research article

    Patients who undergo radiotherapy to treat head and neck cancer can present with several symptoms, including oral ones. The symptoms are usually assessed using instruments to evaluate quality of life. However,...

    Authors: Eliane Marçon Barroso, André Lopes Carvalho, Carlos Eduardo Paiva, Barbara A. Murphy and Bianca Sakamoto Ribeiro Paiva

    Citation: BMC Research Notes 2015 8:522

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  35. Content type: Case Report

    Non-seminomatous germ cell tumours make up about 40 % of all germ cell tumours, which in turn are the most common tumours in men aged 15–44 years. Low risk stage I non-seminomatous germ cell tumours, which are...

    Authors: Tobias Janowitz, Sarah Welsh, Anne Y. Warren, Jane Robson, Benjamin Thomas, Ashley Shaw, Nicola L. Ainsworth, David E. Neal and Danish Mazhar

    Citation: BMC Research Notes 2015 8:524

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  36. Content type: Short Report

    Recently, we have shown that the ATP-binding cassette (ABC) transporter ABCB1 interferes with the anti-cancer activity of the pan-aurora kinase inhibitor tozasertib (VX680, MK-0457) but not of the aurora kinas...

    Authors: Martin Michaelis, Florian Selt, Florian Rothweiler, Michael Wiese and Jindrich Cinatl Jr.

    Citation: BMC Research Notes 2015 8:484

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  37. Content type: Short Report

    To detect and quantify circulating tumour cells (CTCs) in peripheral blood of patients with uveal melanoma primary non-metastatic tumours, and to analyze the possible relationship between CTCs and clinical ris...

    Authors: Manuel F. Bande, Maria Santiago, Laura Muinelo-Romay, Maria Jose Blanco, Purificacion Mera, Carmela Capeans, Maria Pardo and Antonio Piñeiro

    Citation: BMC Research Notes 2015 8:452

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  38. Content type: Research article

    Kaposi’s Sarcoma is the most common sarcoma and second most prevalent cancer seen in Tanzania. Little is known about Kaposi’s sarcoma in our setting as there is paucity of recent published data regarding this ...

    Authors: Phillipo L. Chalya, Fidelis Mbunda, Peter F. Rambau, Hyasinta Jaka, Nestory Masalu, Mariam Mirambo, Martha F. Mushi and Samuel E. Kalluvya

    Citation: BMC Research Notes 2015 8:440

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  39. Content type: Case Report

    Hepatocellular carcinoma (HCC) usually affects patients aged 50–70 years but earlier onset (25–40 years) may occur in hepatitis B endemic areas. 70–90 % of HCC develop on a background of cirrhosis. However, he...

    Authors: Elroy P. Weledji, Dickson S. Nsagha, George Enoworock and Maurice Mouladje

    Citation: BMC Research Notes 2015 8:415

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  40. Content type: Case Report

    Primary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment...

    Authors: Santino Minichillo, Maria Abbondanza Pantaleo, Margherita Nannini, Fabio Coccolo, Lidia Gatto, Guido Biasco and Giovanni Brandi

    Citation: BMC Research Notes 2015 8:325

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  41. Content type: Research article

    Numerous oral anticancer chemotherapies are available. Non-adherence or over-adherence to these chemotherapies can lead to lowered efficacy and increased risk of adverse events. The objective of this study was...

    Authors: Aurélie Bourmaud, Emilie Henin, Fabien Tinquaut, Véronique Regnier, Chloé Hamant, Olivier Colomban, Benoit You, Florence Ranchon, Jérôme Guitton, Pascal Girard, Gilles Freyer, Michel Tod, Catherine Rioufol, Véronique Trillet-Lenoir and Franck Chauvin

    Citation: BMC Research Notes 2015 8:291

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  42. Content type: Research article

    Mitochondrion is a small organelle inside the eukaryotic cells. It has its own genome (mtDNA) and encodes for proteins that are critical for energy production and cellular metabolism. Mitochondrial dysfunction...

    Authors: Asan Meera Sahib Haja Mohideen, Elizabeth Dicks, Patrick Parfrey, Roger Green and Sevtap Savas

    Citation: BMC Research Notes 2015 8:272

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  43. Content type: Research article

    Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which is an effective treatment for patients with non-small cell lung cancer (NSCLC), especially those harboring activating EGFR ...

    Authors: Hiroyuki Minemura, Hiroshi Yokouchi, Keisuke Azuma, Ken-ichiro Hirai, Satoko Sekine, Kengo Oshima, Kenya Kanazawa, Yoshinori Tanino, Yayoi Inokoshi, Taeko Ishii, Yutaka Katsuura, Akio Oishi, Takashi Ishida and Mitsuru Munakata

    Citation: BMC Research Notes 2015 8:220

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  44. Content type: Short Report

    In cancer cells in vitro, the glycolytic pathway and the mitochondrial tricarboxylic acid (TCA) cycle are programmed to produce more precursor molecules, and relatively less ATP, than in differentiated cells. ...

    Authors: Emmanuelle Grillon, Régine Farion, Moshe Reuveni, Andrew Glidle, Chantal Rémy and Jonathan A. Coles

    Citation: BMC Research Notes 2015 8:207

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  45. Content type: Short Report

    Increased expression of the epidermal growth factor receptor (EGFR) is observed in more than 90% of all head and neck squamous cell carcinomas (HNSCC). Therefore, EGFR has emerged as a promising therapeutic ta...

    Authors: Carolien Boeckx, Jolien Van den Bossche, Ines De Pauw, Marc Peeters, Filip Lardon, Marc Baay and An Wouters

    Citation: BMC Research Notes 2015 8:203

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