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  1. Content type: Research article

    Breast cancer (BC) is considered to be one of the most important causes of death worldwide, and it affects the Iranian female population a decade earlier than female in other parts of the world. Human telomera...

    Authors: Mohammad Hashemi, Shadi Amininia, Mahboubeh Ebrahimi, Seyed Mehdi Hashemi, Mohsen Taheri and Saeid Ghavami

    Citation: BMC Research Notes 2014 7:895

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  2. Content type: Research article

    Inflammatory breast cancer (IBC) is an extremely malignant form of breast cancer which can be easily misdiagnosed. Conclusive prognostic IBC molecular biomarkers which are also providing the perspectives for t...

    Authors: Diana V Maltseva, Vladimir V Galatenko, Timur R Samatov, Svetlana O Zhikrivetskaya, Nadezhda A Khaustova, Ilya N Nechaev, Maxim U Shkurnikov, Alexey E Lebedev, Irina A Mityakina, Andrey D Kaprin, Udo Schumacher and Alexander G Tonevitsky

    Citation: BMC Research Notes 2014 7:871

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  3. Content type: Research article

    Curative treatments for patients with metastatic synovial sarcoma (SS) do not exist, and such patients have a poor prognosis. We explored combinations of molecularly-targeted and cytotoxic agents to identify s...

    Authors: Sherif S Morgan and Lee D Cranmer

    Citation: BMC Research Notes 2014 7:812

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  4. Content type: Short Report

    Various kinase inhibitors are known to be ATP-binding cassette (ABC) transporter substrates and resistance acquisition to kinase inhibitors has been associated to increased ABC transporter expression. Here, we...

    Authors: Martin Michaelis, Florian Rothweiler, Thomas Nerreter, Marijke van Rikxoort, Richard Zehner, Wilhelm G Dirks, Michael Wiese and Jindrich Cinatl Jr

    Citation: BMC Research Notes 2014 7:710

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  5. Content type: Research article

    Retinoic acid (RA) is a critical regulator of cell differentiation, proliferation, and apoptosis in various cell types. Recently, the RA-metabolizing enzyme CYP26A1 (cytochrome P450, family 26, subfamily A, po...

    Authors: Makoto Osanai and Gang-Hong Lee

    Citation: BMC Research Notes 2014 7:697

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  6. Content type: Research article

    Cancer therapy in Malaysia primarily focuses on the clinical management of patients with cancer and malnutrition continues to be one of the major causes of death in these patients. There is a dearth of informa...

    Authors: Kavitha Menon, Shariza Abdul Razak, Karami A Ismail and Bhavaraju Venkata Murali Krishna

    Citation: BMC Research Notes 2014 7:680

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  7. Content type: Research article

    Recently, it has been shown that 5-fluorouracil (5-FU) with a strong dihydropyrimidine dehydrogenase (DPD) inhibitor elicits a significant response in bladder cancer with a high level of DPD. However, only a f...

    Authors: Hiroki Ide, Eiji Kikuchi, Shuji Mikami, Akira Miyajima and Mototsugu Oya

    Citation: BMC Research Notes 2014 7:646

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  8. Content type: Case Report

    Adenocarcinoma of the lung with EML4-ALK translocation is a rare subtype of Non Small-Cell Lung Cancer (NSCLC) that has recently shown to benefit from treatment with crizotinib. Despite the concerns about the ...

    Authors: Alessandra Bearz, Sandra Santarossa, Antonio Manfrè, Giorgio Beltrame, Martina Urbani, Ivana Sartor, Valentina Da Ros and Umberto Tirelli

    Citation: BMC Research Notes 2014 7:589

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  9. Content type: Research article

    Breast cancer (BC) is the most frequent cancer in women, accounting for 28% of all tumors among women in Catalonia (Spain). Mastectomy has been replaced over time by breast-conserving surgery (BCS) although no...

    Authors: Josep M Escribà, Laura Pareja, Laura Esteban, Jordi Gálvez, Angels Melià, Laura Roca, Ramon Clèries, Xavier Sanz, Montse Bustins, María J Pla, Miguel J Gil, Josep M Borrás and Josepa Ribes

    Citation: BMC Research Notes 2014 7:587

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  10. Content type: Research article

    The advent of high-throughput technologies to profile human tumors has generated unprecedented insight into our molecular understanding of cancer. However, analysis of such high dimensional data is challenging...

    Authors: Sam D Chorlton, Robin M Hallett and John A Hassell

    Citation: BMC Research Notes 2014 7:546

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  11. Content type: Short Report

    Triple negative breast cancer (TNBC) and often basal-like cancers are defined as negative for estrogen receptor, progesterone receptor and Her2 gene expression. Over the past few years an incredible amount of ...

    Authors: Audrey Player, Tim Oguamanam, Jennifer Okanmelu, Kayla Burrell and Mario Hollomon

    Citation: BMC Research Notes 2014 7:501

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  12. Content type: Research article

    The epidermal growth factor receptor family is expressed in breast cancer, and agents targeting this pathway have single agent effects (e.g. traztuzumab). Development of resistance may be due to the presence o...

    Authors: Sharon Glaysher, Louise M Bolton, Penny Johnson, Christopher Torrance and Ian A Cree

    Citation: BMC Research Notes 2014 7:397

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  13. Content type: Research article

    Targeted therapy against the Epidermal Growth Factor Receptor (EGFR) is among the most promising molecular therapeutics for Head and Neck Squamous Cell Carcinoma (HNSCC). However, drug resistance limits the cl...

    Authors: Carolien Boeckx, Christine Weyn, Isabelle Vanden Bempt, Vanessa Deschoolmeester, An Wouters, Pol Specenier, Carl Van Laer, Danielle Van den Weyngaert, Mark Kockx, Jan B Vermorken, Marc Peeters, Patrick Pauwels, Filip Lardon and Marc Baay

    Citation: BMC Research Notes 2014 7:337

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  14. Content type: Research article

    Over 50% of colorectal cancer (CRC) patients develop metastases. The aim of this study was to evaluate efficacy and tolerance of first-line FOLFIRI® + bevacizumab (B) treatment for metastatic CRC, and to asses...

    Authors: Yves Bécouarn, Laurent Cany, Marina Pulido, Richard Beyssac, Patrick Texereau, Valérie Le Morvan, Dominique Béchade, René Brunet, Sofiane Aitouferoukh, Caroline Lalet, Simone Mathoulin-Pélissier, Marianne Fonck and Jacques Robert

    Citation: BMC Research Notes 2014 7:260

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  15. Content type: Research article

    Thyroid cancer is the most common endocrine-related cancer in the United States and its incidence is rising rapidly. Since among various genetic lesions identified in thyroid cancer, the BRAFV600E mutation is ...

    Authors: Elyse K Hanly, Shilpi Rajoria, Zbigniew Darzynkiewicz, Hong Zhao, Robert Suriano, Neha Tuli, Andrea L George, Robert Bednarczyk, Edward J Shin, Jan Geliebter and Raj K Tiwari

    Citation: BMC Research Notes 2014 7:187

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